Alpha-difluoromethylornithine
Alpha-difluoromethylornithine Uses, Dosage, Side Effects, Food Interaction and all others data.
Alpha-difluoromethylornithine prevents hair growth by inhibiting the anagen phase of hair production. This occurs by eflornithine irreversibly binding (also called suicide inhibition) to ornithine decarboxylase (ODC) and physically preventing the natural substrate ornithine from accessing the active site.
Trade Name | Alpha-difluoromethylornithine |
Generic | Eflornithine |
Eflornithine Other Names | alpha-difluoromethylornithine, DFMO, Eflornithine |
Type | |
Formula | C6H12F2N2O2 |
Weight | Average: 182.171 Monoisotopic: 182.08668396 |
Groups | Approved, Withdrawn |
Therapeutic Class | Hair Growth Inhibitor |
Manufacturer | |
Available Country | |
Last Updated: | September 19, 2023 at 7:00 am |
Uses
Alpha-difluoromethylornithine Hydrochloride cream, 13.9% is used for the reduction of unwanted facial hair in women. Alpha-difluoromethylornithine Hydrochloride has only been studied on the face and adjacent involved areas under the chin of affected individuals. Usage should be limited to these areas of involvement.
Alpha-difluoromethylornithine is also used to associated treatment for these conditions: Meningoencephalitic stage Trypanosoma brucei gambiense infection, Hair removal therapy
How Alpha-difluoromethylornithine works
Alpha-difluoromethylornithine prevents hair growth by inhibiting the anagen phase of hair production. This occurs by eflornithine irreversibly binding (also called suicide inhibition) to ornithine decarboxylase (ODC) and physically preventing the natural substrate ornithine from accessing the active site.
Dosage
Alpha-difluoromethylornithine dosage
Adults: Apply a thin layer of Alpha-difluoromethylornithine cream, 13.9% to affected areas of the face and adjacent involved areas under the chin and rub in thoroughly. Do not wash treated area for at least 4 hours. Use twice daily at least 8 hours apart or as directed by a physician. The patient should continue to use hair removal techniques as needed in conjunction with Alpha-difluoromethylornithine (Wonica should be applied at least 5 minutes after hair removal). Cosmetics or sunscreens may be applied over treated areas after cream has dried.
.Elderly: No apparent differences in safety were observed between older patients and younger patients.
Children: The safety and effectiveness of this product have not been established in pediatric patients less than 12 years of age.
Side Effects
Adverse events were primarily mild in intensity and generally resolved without medical treatment or discontinuation of Alpha-difluoromethylornithine. Side effects can include acne, barbae, pseudofolliculitis, stinging skin, headache, burning skin, dry skin, erythema (redness), pruritus (itching), tingling skin, dyspepsia, skin irritation, rash, alopecia, dizziness, folliculitis, hair ingrown, facial edema, anorexia, nausea, asthenia, vertigo.
Precaution
For external use only. Transient stinging or burning may occur when applied to abraded or broken skin.
Interaction
It is not known whether Alpha-difluoromethylornithine has any interaction with other topically applied drug products.
Food Interaction
No interactions found.Half Life
8 hours
Elimination Route
Renal
Pregnancy & Breastfeeding use
Pregnancy Category C. It is not known whether or not Alpha-difluoromethylornithine Hydrochloride is excreted in human milk. Caution should be exercised when Alpha-difluoromethylornithine is administered to a nursing woman.
Contraindication
Alpha-difluoromethylornithine is contraindicated in patients with a history of sensitivity to any components of the preparation.
Special Warning
Store at 25°C, excursions permitted to 15°C-30°C. Do not freeze.
Acute Overdose
Overdosage information with Alpha-difluoromethylornithine is unavailable. However, if very high topical doses (e.g., multiple tubes per day) or oral ingestion has been encountered (a 30 gm tube contains 4.2 gm of Alpha-difluoromethylornithine Hydrochloride), the patient should be monitored, and appropriate supportive measures should be administered as necessary.
Storage Condition
Store at 25°C, excursions permitted to 15°C-30°C. Do not freeze.
Innovators Monograph
You find simplified version here Alpha-difluoromethylornithine
Alpha-difluoromethylornithine contains Eflornithine see full prescribing information from innovator Alpha-difluoromethylornithine Monograph, Alpha-difluoromethylornithine MSDS, Alpha-difluoromethylornithine FDA label