Aluminum Zirconium Octachlorohydrex Gly
Aluminum Zirconium Octachlorohydrex Gly Uses, Dosage, Side Effects, Food Interaction and all others data.
Aluminum Zirconium Octachlorohydrex Gly is complex that consists of aluminum zirconium octachlorohydrate and glycine. It is an active antiperspirant agent , . It diffuses into the sweat pores and prevents perspiration (sweat) from leaving the pores. The anhydrous form of the compound also has water-absorbing properties. Currently, the FDA allows the inclusion of this substance in concentrations of up to 20% in antiperspirants .
Interestingly, this chemical has been studied in relation to its possible impact on the microbiome of the human underarms .
Reduces perspiration and body odor .
| Trade Name | Aluminum Zirconium Octachlorohydrex Gly |
| Generic | Aluminum zirconium octachlorohydrex gly |
| Aluminum zirconium octachlorohydrex gly Other Names | Aluminium zirconium octachlorohydrex gly, Aluminium zirconium octachlorohydrex glycine complex, Aluminum zirconium octachlorohydrex gly, Aluminum zirconium octachlorohydrex glycine complex |
| Type | |
| Formula | C2H8AlClNO4Zr |
| Weight | Average: 263.74 Monoisotopic: 261.89768 |
| Groups | Approved |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Aluminum Zirconium Octachlorohydrex Gly is an antiperspirant used to reduce sweating.
Aluminum-based antiperspirant preparations intended for the reduction of normal underarm perspiration, and indicated for use in hyperhidrosis .
How Aluminum Zirconium Octachlorohydrex Gly works
Aluminium salts in antiperspirants, such as chlorohydrates, form insoluble plugs within sweat ducts to temporarily prevent sweat reaching the surface of the skin , , , .
Toxicity
The EU has published a statement of caution that antiperspirant should not be applied to damaged or irritated skin, yet it is common to shave the underarm area before applying antiperspirant .
The possible health risks of aluminum containing antiperspirant use are not well studied. Although it has been suggested that deodorant and/or antiperspirant use is associated with incidence or age of breast cancer diagnosis , a causal relationship between aluminium product use and breast cancer has not been established , .
The oral toxicity of aluminium compounds for which data are available (bromide, nitrate, chloride and sulfate) is moderate to low, with LD50 values in the range of 162 to 750 mg Al/kg in rats, and from 164 to 980 mg Al/kg in mice, depending on the type of aluminium compound studied .
Food Interaction
No interactions found.Elimination Route
A preliminary study of the dermal absorption of aluminium from antiperspirants using aluminum-26 was performed. After repeated exposure for 6 days to aluminum chlorohydrate 21 % (about 13 mg of aluminium) to each axilla under occlusive dressing in two volunteers (one man and a woman), on skin previously tape stripped twice, blood and urine samples were obtained. Aluminium was detected in the blood 6 hours after the primary application and remained detectable for 15 days therafter. The results of this study estimate that the proportion of aluminium is absorbed averaged 0.012%. The shortcomings of this study are that it was not done in accordance with good practice (GCP) and it was performed using only 2 volunteers .
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