Ampicillin Pivaloyloxymethyl Ester

Ampicillin Pivaloyloxymethyl Ester Uses, Dosage, Side Effects, Food Interaction and all others data.

Pivalate ester analog of ampicillin.

Ampicillin Pivaloyloxymethyl Ester is the pivaloyloxymethyl ester of (the semi-synthetic penicillin) ampicillin. It is an inactive pro-drug, which is converted during its absorption from the gastrointestinal tract to the microbiologically active ampicillin, together with formaldehyde and pivalic acid, by non-specific esterases present in most body tissues. Amounts in excess of 99% of the pivampicillin absorbed are converted to ampicillin within 15 minutes of absorption.

Table Of contents

• Ampicillin Pivaloyloxymethyl Ester
• Uses
• Dosage
• Side Effect
• Precautions
• Interactions
• Uses during Pregnancy
• Uses during Breastfeeding
• Accute Overdose
• Food Interaction
• Half Life
• Volume of Distribution
• Clearance
• Interaction With other Medicine
• Contradiction
• Storage

Trade Name	Ampicillin Pivaloyloxymethyl Ester
Generic	Pivampicillin
Pivampicillin Other Names	Ampicillin pivaloyloxymethyl ester, Pivaloylampicillin, Pivaloyloxymethyl ampicillinate, Pivampicilina, Pivampicillin, Pivampicilline, Pivampicillinum
Type
Formula	C22H29N3O6S
Weight	Average: 463.547 Monoisotopic: 463.177706365
Groups	Approved
Therapeutic Class
Manufacturer
Available Country
Last Updated:	September 19, 2023 at 7:00 am

Uses

Ampicillin Pivaloyloxymethyl Ester is an ampicillin prodrug used to treat a variety of infections.

or the treatment of respiratory tract infections (including acute bronchitis, acute exacerbations of chronic bronchitis and pneumonia); ear, nose and throat infections; gynecological infections; urinary tract infections (including acute uncomplicated gonococcal urethritis) when caused by non penicillinase-producing susceptible strains of the following organisms: gram-positive organisms, e.g., streptococci, pneumococci and staphylococci; gram-negative organisms, e.g., H. influenzae, N. gonorrhoeae, E. coli, P. mirabilis.

Ampicillin Pivaloyloxymethyl Ester is also used to associated treatment for these conditions: Susceptible Bacterial Infections

How Ampicillin Pivaloyloxymethyl Ester works

Ampicillin (the active metabolite of pivampicillin) has a bactericidal action resulting from inhibition of cell wall mucopeptide biosynthesis.

Food Interaction

• Take with or without food. The absorption is unaffected by food.

Elimination Route

Absorbed following oral administration.

Half Life

Approximately 1 hour.

Innovators Monograph

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