Aprobarbitale

Aprobarbitale Uses, Dosage, Side Effects, Food Interaction and all others data.

Aprobarbitale is a barbiturate derivative synthesized in the 1920s by Ernst Preiswerk. It was determined that the substance was capable of demonstrating sedative, hypnotic, and anticonvulsant effects. A primary treatment indicated for the use of aprobarbital was subsequently insomnia. Aprobarbitale was never as widely used as more common barbiturate derivatives such as phenobarbital and is now rarely prescribed.

Trade Name Aprobarbitale
Generic Aprobarbital
Aprobarbital Other Names Allypropymal, Aprobarbital, Aprobarbitale, Aprobarbitalum
Type
Formula C10H14N2O3
Weight Average: 210.2298
Monoisotopic: 210.100442324
Groups Experimental, Illicit
Therapeutic Class
Manufacturer
Available Country
Last Updated: September 19, 2023 at 7:00 am
Aprobarbitale
Aprobarbitale

How Aprobarbitale works

Aprobarbitale (like all barbiturates) works by binding to the GABAA receptor at either the alpha or the beta sub unit. These are binding sites that are distinct from GABA itself and also distinct from the benzodiazepine binding site. Like benzodiazepines, barbiturates potentiate the effect of GABA at this receptor. This GABAA receptor binding decreases input resistance, depresses burst and tonic firing, especially in ventrobasal and intralaminar neurons, while at the same time increasing burst duration and mean conductance at individual chloride channels; this increases both the amplitude and decay time of inhibitory postsynaptic currents. In addition to this GABA-ergic effect, barbiturates also block the AMPA receptor, a subtype of glutamate receptor. Glutamate is the principal excitatory neurotransmitter in the mammalian CNS. Aprobarbitale also appears to bind neuronal nicotinic acetylcholine receptors.

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You find simplified version here Aprobarbitale

http://classyfire.wishartlab.com/tax_nodes/C0000000
http://classyfire.wishartlab.com/tax_nodes/C0000002
http://classyfire.wishartlab.com/tax_nodes/C0001346
http://classyfire.wishartlab.com/tax_nodes/C0000075
http://classyfire.wishartlab.com/tax_nodes/C0000292
http://classyfire.wishartlab.com/tax_nodes/C0002023
http://classyfire.wishartlab.com/tax_nodes/C0002389
http://classyfire.wishartlab.com/tax_nodes/C0003033
http://classyfire.wishartlab.com/tax_nodes/C0004139
http://classyfire.wishartlab.com/tax_nodes/C0004557
http://classyfire.wishartlab.com/tax_nodes/C0000278
http://classyfire.wishartlab.com/tax_nodes/C0003940
http://classyfire.wishartlab.com/tax_nodes/C0004150
http://classyfire.wishartlab.com/tax_nodes/C0001831
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:2791
http://www.hmdb.ca/metabolites/HMDB0015441
http://www.genome.jp/dbget-bin/www_bget?drug:D00698
http://www.genome.jp/dbget-bin/www_bget?cpd:C07826
https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=6464
https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46504558
https://www.chemspider.com/Chemical-Structure.6221.html
https://mor.nlm.nih.gov/RxNav/search?searchBy=RXCUI&searchTerm=17381
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=2791
https://www.ebi.ac.uk/chembldb/index.php/compound/inspect/CHEMBL7863
https://zinc.docking.org/substances/ZINC000018167382
http://bidd.nus.edu.sg/group/cjttd/ZFTTDDRUG.asp?ID=DAP001034
http://www.pharmgkb.org/drug/PA164754809
https://en.wikipedia.org/wiki/Aprobarbital
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