Butethal

Butethal Uses, Dosage, Side Effects, Food Interaction and all others data.

Butethal is a sedative and a hypnotic drug.

Butethal (also known as butobarbitone and butobarbital) belongs to a group of medicines called the barbiturates. It is thought to act on receptors in the brain (GABA receptors) causing the release of the chemical GABA. This chemical inhibits certain areas of the brain resulting in sleepiness.

Trade Name Butethal
Generic Butobarbital
Butobarbital Other Names Butethal, Butobarbital, Butobarbitone
Type
Formula C10H16N2O3
Weight Average: 212.2456
Monoisotopic: 212.116092388
Groups Approved, Illicit
Therapeutic Class
Manufacturer
Available Country
Last Updated: September 19, 2023 at 7:00 am
Butethal
Butethal

Uses

For the treatment of insomnia.

How Butethal works

Butethal binds at a distinct binding site associated with a Cl- ionopore at the GABAA receptor, increasing the duration of time for which the Cl- ionopore is open. The post-synaptic inhibitory effect of GABA in the thalamus is, therefore, prolonged. All of these effects are associated with marked decreases in GABA-sensitive neuronal calcium conductance (gCa). The net result of barbiturate action is acute potentiation of inhibitory GABAergic tone. Barbiturates also act through potent (if less well characterized) and direct inhibition of excitatory AMPA-type glutamate receptors, resulting in a profound suppression of glutamatergic neurotransmission.

Toxicity

Signs of overdose include confusion (severe), decrease in or loss of reflexes, drowsiness (severe), fever, irritability (continuing), low body temperature, poor judgment, shortness of breath or slow or troubled breathing, slow heartbeat, slurred speech, staggering, trouble in sleeping, unusual movements of the eyes, weakness (severe).

Elimination Route

Rapidly absorbed following oral administration.

Half Life

37 hours

Innovators Monograph

You find simplified version here Butethal

*** Taking medicines without doctor's advice can cause long-term problems.
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