Azimilide

Azimilide Uses, Dosage, Side Effects, Food Interaction and all others data.

Azimilide is an investigational class III anti-arrhythmic drug that blocks fast and slow components of the delayed rectifier cardiac potassium channels. It is not approved for use in any country, but is currently in clinical trials in the United States.

Azimilide is a new class III anti-arrhythmic agent. It is distinguished by a relative lack of reverse use-dependence, excellent oral absorption, no need for dose titration, an option for out-patient initiation, no need for adjustment associated with renal or liver failure and a lack of interaction with warfarin or digoxin. It carries some risk of torsade de pointes and rarely, neutropoenia.

Trade Name Azimilide
Generic Azimilide
Azimilide Other Names Azimilide
Type
Formula C23H28ClN5O3
Weight Average: 457.96
Monoisotopic: 457.1880675
Groups Investigational
Therapeutic Class
Manufacturer
Available Country
Last Updated: September 19, 2023 at 7:00 am
Azimilide
Azimilide

Uses

Investigated for use/treatment in arrhythmia and atrial fibrillation.

How Azimilide works

The mechanism of action of azimilide is to block both the slowly conducting (I(Ks)) and rapidly conducting (I(Kr)) rectifier potassium currents in cardiac cells. This differs from other class III agents that block I(Kr) exclusively or in combination with sodium, calcium, or transient outward (I(to)) potassium current channels. It also has blocking effects on sodium (I(Na)) and calcium currents (I(CaL)). Its effects on reentrant circuits in infarct border zones causing ventricular tachyarrhythmias are unknown.

Elimination Route

Excellent oral absorption.

Innovators Monograph

You find simplified version here Azimilide

*** Taking medicines without doctor's advice can cause long-term problems.
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