Bexxar Dosimetric

Bexxar Dosimetric Uses, Dosage, Side Effects, Food Interaction and all others data.

Murine IgG2a lambda monoclonal antibody against CD20 antigen (2 heavy chains of 451 residues, 2 lambda chains of 220 residues). It is produced in an antibiotic-free culture of mammalian cells. It can be covalently linked to Iodine 131 (a radioactive isotope of iodine).

Bexxar Dosimetric binds to the CD20 antigen, which is predominantly expressed on mature B cells and on >90% of B-cell non-Hodgkin's lympohomas. The antibody leads to selective killing of B-cells.

Bexxar Dosimetric
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Uses during Breastfeeding
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Trade Name	Bexxar Dosimetric
Availability	Prescription only
Generic	Tositumomab
Tositumomab Other Names	Tositumomab
Related Drugs	methotrexate, rituximab, glucagon, Rituxan, cyclophosphamide, mannitol, vincristine, Imbruvica, Tubersol
Type
Formula	C₆₄₁₆H₉₈₇₄N₁₆₈₈O₁₉₈₇S₄₄
Weight	143859.7 Da
Groups	Approved, Investigational
Therapeutic Class
Manufacturer
Available Country	United States
Last Updated:	September 19, 2023 at 7:00 am

Uses

Bexxar Dosimetric is a monoclonal anti-CD20 antibody used to treat B-cell non-Hodgkin's lymphoma via a conjugated radioactive isotope.

For treatment of non-Hodgkin's lymphoma (CD20 positive, follicular)

How Bexxar Dosimetric works

Binds to the CD20 antigen which is found on mature B lymphocytes. The antibody binding appears to induce apoptosis, complement-dependent cytotoxicity and cell death through ionizing radiation.