Bexxar Dosimetric

Bexxar Dosimetric Uses, Dosage, Side Effects, Food Interaction and all others data.

Murine IgG2a lambda monoclonal antibody against CD20 antigen (2 heavy chains of 451 residues, 2 lambda chains of 220 residues). It is produced in an antibiotic-free culture of mammalian cells. It can be covalently linked to Iodine 131 (a radioactive isotope of iodine).

Bexxar Dosimetric binds to the CD20 antigen, which is predominantly expressed on mature B cells and on >90% of B-cell non-Hodgkin's lympohomas. The antibody leads to selective killing of B-cells.

Trade Name Bexxar Dosimetric
Availability Prescription only
Generic Tositumomab
Tositumomab Other Names Tositumomab
Related Drugs methotrexate, rituximab, glucagon, Rituxan, cyclophosphamide, mannitol, vincristine, Imbruvica, Tubersol
Type
Formula C6416H9874N1688O1987S44
Weight 143859.7 Da
Groups Approved, Investigational
Therapeutic Class
Manufacturer
Available Country United States
Last Updated: September 19, 2023 at 7:00 am
Bexxar Dosimetric
Bexxar Dosimetric

Uses

Bexxar Dosimetric is a monoclonal anti-CD20 antibody used to treat B-cell non-Hodgkin's lymphoma via a conjugated radioactive isotope.

For treatment of non-Hodgkin's lymphoma (CD20 positive, follicular)

How Bexxar Dosimetric works

Binds to the CD20 antigen which is found on mature B lymphocytes. The antibody binding appears to induce apoptosis, complement-dependent cytotoxicity and cell death through ionizing radiation.

Half Life

0.8 hours (mammalian reticulocytes, in vitro)

Clearance

  • 68.2 mg/hr [patients with NHL]

Elimination Route

Elimination of Iodine-131 occurs by decay and excretion in the urine.

Innovators Monograph

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*** Taking medicines without doctor's advice can cause long-term problems.
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