Bisoctrizole

Bisoctrizole Uses, Dosage, Side Effects, Food Interaction and all others data.

Bisoctrizole, or methylene bis-benzotriazolyl tetramethylbutylphenol, is a broad-spectrum organic UV filter that is marketed as Tinosorb M . It is a benzotriazole-based organic compound that absorbs, reflects, and scatters both UV-A and UV-B rays. Bisoctrizole is not approved by the FDA, but is approved in the EU and other parts of the world as a UV-filter in sunscreens, day care products and skin lightening products at a maximum concentration of 10% .

Under the conditions of in vitro androgen competitive binding assay, bisoctrizole displayed no intrinsic androgenic, estrogenic, nor uterotrophic activity .

Bisoctrizole
Uses
Dosage
Side Effect
Precautions
Interactions
Uses during Pregnancy
Uses during Breastfeeding
Accute Overdose
Food Interaction
Half Life
Volume of Distribution
Clearance
Interaction With other Medicine
Contradiction
Storage

Trade Name	Bisoctrizole
Generic	Bisoctrizole
Bisoctrizole Other Names	Bisoctrizole, MBBT
Type
Formula	C₄₁H₅₀N₆O₂
Weight	Average: 658.891 Monoisotopic: 658.399524874
Protein binding	No pharmacokinetic data available.
Groups	Approved
Therapeutic Class
Manufacturer
Available Country
Last Updated:	September 19, 2023 at 7:00 am

Uses

Bisoctrizole is an absorber of UVA and UVB radiation used in sunscreen.

Indicated for use as a sunscreen agent in cosmetic products.

Bisoctrizole is also used to associated treatment for these conditions: Sunburn

How Bisoctrizole works

Bisoctrizole is an organic UV-A filter that absorbs both UV-A and UV-B rays .

Toxicity

Both oral LD50 and dermal LD50 in rat is > 2000 mg/kg . In a developmental toxicity study of rats, the maternal and developmental no-observed-effect-level (NOEL) of bisoctrizole was the high dose level of 1000 mg/kg bw/day . Animal studies suggest that bisoctrizole mediates no phytotoxic effects .

Food Interaction

No interactions found.

Volume of Distribution

No pharmacokinetic data available.

Elimination Route

A rat and human dermal penetration study in vitro indicates that bisoctrizole displays minimal absorption through the skin, with only about 0.01% and 0.06 % of the applied dose penetration through the human and rat skin membrane, respectively . Despite low dermal uptake, potential bioaccumulation after repeated skin applications cannot be excluded .