BL-1020

BL-1020 Uses, Dosage, Side Effects, Food Interaction and all others data.

BL-1020 is a first in class novel compound for the treatment of schizophrenia. It is being developed by BioLineRx (BioLine).

Extensive preclinical testing of BL-1020 has shown it to have a positive safety and pharmacokinetic profile. BL-1020 reduces dopamine activity while avoiding the side affects associated with unmitigated dopamine blockade. In animal models of schizophrenia, BL-1020 reduces behaviors characteristic of psychosis and causes minimal or no impairment of movement, the most severe side effect of classic antipsychotic drugs. Biochemical testing confirms that BL-1020 works via the mechanism previously established for classic antipsychotics. BL-1020 is structurally and mechanistically distinct from the atypical antipsychotics and is not anticipated to trigger diabetes or elevated cholesterol. Preliminary studies do not reveal toxicity.

Table Of contents

• BL-1020
• Uses
• Dosage
• Side Effect
• Precautions
• Interactions
• Uses during Pregnancy
• Uses during Breastfeeding
• Accute Overdose
• Food Interaction
• Half Life
• Volume of Distribution
• Clearance
• Interaction With other Medicine
• Contradiction
• Storage

Trade Name	BL-1020
Generic	BL-1020
Type
Groups	Investigational
Therapeutic Class
Manufacturer
Available Country
Last Updated:	September 19, 2023 at 7:00 am

Uses

Investigated for use/treatment in schizophrenia and schizoaffective disorders.

How BL-1020 works

In radioligand binding studies, BL-1020 displayed strong interaction with dopamine receptors especially D_2L and D_2S (K_i of 0.27 nM and 0.17 nM respectively), the serotonin receptor 5-HY_2a (K_i 0.25 nM) as well as moderate interaction with the GABAA receptor (K_i 3.29 microK).

Elimination Route

Orally available.

Innovators Monograph

You find simplified version here BL-1020