Calaclear (obsolete)
Calaclear (obsolete) Uses, Dosage, Side Effects, Food Interaction and all others data.
Calaclear (obsolete) (also known as pramoxine or pramoxine HCI) is a topical anesthetic and antipruritic. It is used for many dermatological and anorectal/anogenital conditions including minor cuts/burns, insect bites, hives/rashes due to poison ivy exposure, hemorrhoids and other anorectal/anogenital disorders. Calaclear (obsolete) is available by itself and in combination with other medications in various topical preparations. It works by preventing ionic fluctuations needed for neuron membrane depolarization and action potential propagation.
Calaclear (obsolete) temporarily relieves pain, pruritis, burning and discomfort associated with minor lip and skin irritations and hemorrhoid's by inhibiting voltage gated sodium channels on neurons.
| Trade Name | Calaclear (obsolete) |
| Generic | Pramocaine |
| Pramocaine Other Names | Pramocaína, Pramocaine, Pramoxine |
| Weight | 1%, 1%, 1%, 1%, 1%, 1%, 1% |
| Type | Rectal foam, topical cream, topical gel, topical lotion, topical pad, topical spray, topical stick |
| Formula | C17H27NO3 |
| Weight | Average: 293.407 Monoisotopic: 293.199093733 |
| Groups | Approved |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | United States |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Calaclear (obsolete) is a local anesthetic and antipruritic agent found in various topical preparations.
It is indicated for temporary relief of pain and pruritus from minor lip and skin irritations as well as for temporary relief from pain, burning, itching and discomfort associated with hemorrhoids and other anorectal/anogenital disorders.
Calaclear (obsolete) is also used to associated treatment for these conditions: Dermatosis, Hemorrhoids, Itching of the perianal area, Skin Irritation
How Calaclear (obsolete) works
Calaclear (obsolete) reversibly binds and inhibits voltage gated sodium channels on neurons decreasing sodium permeability into the cell. This stabilizes the membrane and prevents ionic fluctuations needed for depolarization stopping any action potential propagation.
Toxicity
LD50 Mouse ip 300 mg/kg, LD50 Mouse sc 750 mg/kg
Food Interaction
No interactions found.Elimination Route
There is minimal absorption after topical administration and it is not given orally.
Innovators Monograph
You find simplified version here Calaclear (obsolete)
FAQ
What is Calaclear (obsolete) use for?
Calaclear (obsolete) is used to decrease swelling, itching and pain that is caused by minor skin irritations or hemorrhoids.It also used for many dermatological and anorectal/anogenital conditions including minor cuts/burns, insect bites, hives/rashes due to poison ivy exposure, hemorrhoids and other anorectal/anogenital disorders.
How safe Calaclear (obsolete) is?
Calaclear (obsolete) is a safe, steroid-free, itch-relieving option that can be used as needed.
What are the common side effects of Calaclear (obsolete)?
Calaclear (obsolete) may cause side effects include:
- redness, irritation, swelling, burning, stinging, or pain at affected area.
- dryness at affected area.
How long can I use Calaclear (obsolete)?
Do not use Calaclear (obsolete) for more than 14 days. Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.Do not use your medicine more often than directed.
Is Calaclear (obsolete) safe for pregnancy?
Calaclear (obsolete) topical should only be given during pregnancy when benefits outweigh risks Calaclear (obsolete) topical has not been formally assigned to a pregnancy category by the FDA. Animal studies have not been reported. There are no controlled data in human pregnancy.
Can I take Calaclear (obsolete) with alcohol?
You should avoid alcohol while you're taking Calaclear (obsolete). You should continue to avoid alcohol for 48 hours after you stop taking medication.
Is Calaclear (obsolete) safe for babies?
Calaclear (obsolete) may safe younger than 2 years baby .Do not use Calaclear (obsolete) for skin irritation in children younger than 2 years unless directed by the doctor.
How long does it take for Calaclear (obsolete) to work?
Clinical studies have shown that Calaclear (obsolete) hydrochloride begins working in as little as two minutes, and its effects last for up to eight hours.
How many times a day can I use Calaclear (obsolete) cream?
Calaclear (obsolete) cream/ointment use once or twice a day. It must not be applied more often than twice a day, and once a day is often sufficient.
Can i use Calaclear (obsolete) on my face?
Calaclear (obsolete) can be used to help relieve itching on the face and body.
How long can I use Calaclear (obsolete)?
You should not use for more than 14 days.
How does Calaclear (obsolete) work?
It works by preventing ionic fluctuations needed for neuron membrane depolarization and action potential propagation.Calaclear (obsolete) is available by itself and in combination with other medications in various topical preparations.
Is Calaclear (obsolete) an anti inflammatory?
Calaclear (obsolete) is a topical aerosol foam containing a corticosteroid used as an anti-inflammatory/anti-itch agent and a local anesthetic used to relieve inflammatory and itching manifestations of corticosteroid-responsive skin conditions .
Is Calaclear (obsolete) good for hemorrhoids?
Calaclear (obsolete) is an anesthetic, or numbing medicine. Calaclear (obsolete) is used to treat pain or itching caused by insect bites, minor burns or scrapes, hemorrhoids, vaginal irritation, and minor skin rash, dryness, or itching.
Does Calaclear (obsolete) stop itching?
Topical treatments that contain hydrochloride can be applied directly to the source of the itch and can, therefore, work to relieve the itch quickly.
Is Calaclear (obsolete) a vasoconstrictor?
There is some evidence to suggest that a recognizable correlation exists between vasoconstrictor potency and therapeutic efficacy in man.
How does Calaclear (obsolete) work?
Calaclear (obsolete) is a drug that aids the body's mucus-clearing processes in the respiratory tract. It is used to relieve chest congestion. This medicine works by blocking a certain natural substance (known as histamine) that your body makes during an allergic reaction.
