Calcium L-threonate
Calcium L-threonate Uses, Dosage, Side Effects, Food Interaction and all others data.
Calcium L-threonate is a calcium salt of threnoic acid and a novel drug developed for the treatment of osteoporosis and as a calcium supplement . It is found in dietary supplements as a source of L-threonate used in the treatment of calcium deficiency and prevention of osteoporosis. The most common form is calcium L-threonate, or (2R,3S)-2,3,4-trihydroxy butyric acid calcium . L-threonate is an active metabolite of vitamin C that mediates a stimulatory action on vitamin C uptake . Therapeutic efficacy of calcium threonate in reducing was studied and investigated due to the hypothesis that it may play a role in the mineralization process through its positive action on vitamin C.
In a preclinical study, calcium L-theronate inhibited the bone resorption of osteoclasts in vitro .
| Trade Name | Calcium L-threonate |
| Generic | Calcium threonate |
| Calcium threonate Other Names | Calcium L-threonate, Threonine, calcium salt |
| Type | |
| Formula | C8H14CaO10 |
| Weight | Average: 310.268 Monoisotopic: 310.0212876 |
| Groups | Approved |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
No approved therapeutic indications.
How Calcium L-threonate works
Once dissociated to calcium and L-theronic acid, L-threonic acid exhibits significant stimulatory action on vitamin C uptake and prolongs the retention of vitamin C in human T-lymphoma cells . Vitamin C is a marker for osteoblast formation and has been shown to stimulate procollagen and enhance collagen synthesis . Via stimulation of vitamin C uptake, L-threonic acid acts as a metabolite that influences the mineralization process .
Toxicity
Calcium L-threonate has low oral acute toxicity, with no adverse effects observed at doses as high as 40 g/kg bw in mice or 32 g/kg bw in rats . In a subchronic study of rats, the NOAEL of 4 g/kg bw/day was reported with the occurrence of reversible effects on blood coagulation and accretion of the thyroid gland . Studies in vitro and in vivo suggest that calcium L-threonate is unlikely to have genotoxic, carcinogenic, or mutagenic potential as L-threonate is an endogenous compound in the body . Reproductive and developmental toxicity studies in mice indicated that calcium L-threonate in doses up to 6 g/kg bw/day has no adverse effect on the fertility and the developing fetus, and did not cause maternal toxicity .
Food Interaction
No interactions found.Volume of Distribution
The apparent total volume of distribution following a single oral dose of 2025 mg calcium theronate in healthy adult Chinese subjects was approximately 53.6 L .
Elimination Route
Human studies demonstrate that calcium from calcium L-threonate is absorbed . In an open-label, single- and multiple-dose study of healthy adult Chinese subjects receiving a single oral dose of 2025 mg calcium theronate, the peak plasma concentration (Cmax) was 32.3 mg/L . The time to reach peak plasma concentration (Tmax) was approximately 2 hours .
Half Life
The terminal-phase elimination half-life following a single oral dose of 2025 mg calcium theronate in healthy adult Chinese subjects was approximately 2.7 hours .
Clearance
Apparent total clearance following a single oral dose of 2025 mg calcium theronate in healthy adult Chinese subjects was approximately 14.5 L/h .
Elimination Route
The presence of threonic acid in human urine has been identified . In a pharmacokinetic study of rats receiving 200 mg/kg bw of calcium threonate orally, approximately 30% of the calcium was excreted in the urine, around 40% was eliminated in the faeces, and about 10 -20% remained in the blood and bone, and about 10% was stored in organs after 24 hours of administration .
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