Calmactin

Calmactin Uses, Dosage, Side Effects, Food Interaction and all others data.

Calmactin is a 5HT-3 antagonist made by Solvay Pharmaceuticals that is currently under trial phase in the EU and US.

Calmactin is an orally formulated medication that blocks the action of 5-hydroxy-tryptamine 3 (5-HT3) receptors. Phase III studies of cilansetron had been suspended by Solvay in order to assess whether the drug possesses safety concerns similar to alosetron. Alosetron, also a 5-HT3 antagonist, was withdrawn from the market due to questions regarding its safety. Phase III testing with cilansetron has since resumed. In June 2005 the company announced that they were reviewing the priority of the cilansetron program.

Trade Name Calmactin
Generic Cilansetron
Cilansetron Other Names Cilansetron
Type
Formula C20H21N3O
Weight Average: 319.4002
Monoisotopic: 319.168462309
Groups Investigational
Therapeutic Class
Manufacturer
Available Country
Last Updated: September 19, 2023 at 7:00 am
Calmactin
Calmactin

Uses

For the treatment of symptoms associated with irritable bowel syndrome.

How Calmactin works

Calmactin is a potent and selective 5-HT3 receptor antagonist. 5-HT3 receptors are nonselective cation channels that are extensively distributed on enteric neurons in the human gastrointestinal tract, as well as other peripheral and central locations. Activation of these channels and the resulting neuronal depolarization affect the regulation of visceral pain, colonic transit and gastrointestinal secretions, processes that relate to the pathophysiology of irritable bowel syndrome (IBS). 5-HT3 receptor antagonists such as cilansetron inhibit activation of non-selective cation channels which results in the modulation of the enteric nervous system.

Elimination Route

Rapidly absorbed orally with a bioavailability of greater than 80% in rats.

Half Life

The elimination half-life after 4- and 8-mg oral doses administered 3 times daily for 6 days was reported to be 1.6 to 1.9 hours.

Innovators Monograph

You find simplified version here Calmactin

*** Taking medicines without doctor's advice can cause long-term problems.
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