Octastatin

Octastatin Uses, Dosage, Side Effects, Food Interaction and all others data.

Octastatin is a synthetic octapeptide somatostatin analog. It was being studied for the treatment of cancer.

Octastatin is a somatostatin analog with a higher metabolic stability than the parent hormone. Octastatin reduces splanchnic blood flow; inhibits growth hormone release, and inhibits the release of peptides and vasoactive compounds from neuroendocrine tumors.

Octastatin
Uses
Dosage
Side Effect
Precautions
Interactions
Uses during Pregnancy
Uses during Breastfeeding
Accute Overdose
Food Interaction
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Interaction With other Medicine
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Trade Name	Octastatin
Generic	Vapreotide
Vapreotide Other Names	Vapreotida, Vapreotide, Vapreotidum
Type
Formula	C₅₇H₇₀N₁₂O₉S₂
Weight	Average: 1131.38 Monoisotopic: 1130.48301423
Groups	Experimental, Investigational
Therapeutic Class
Manufacturer
Available Country
Last Updated:	September 19, 2023 at 7:00 am

Uses

For the treatment of esophageal variceal bleeding in patients with cirrhotic liver disease and has also shown efficacy in the treatment of patients with AIDS-related diarrhea.

How Octastatin works

The exact mechanism of action is unknown, although one study has provided in vitro and in vivo evidence for a tachykinin NK1 receptor antagonist effect in the analgesic effects of vapreotide (PMID: 7556407).

Toxicity

Safety data are limited, however, headache, fatigue, diarrhea, nausea, vomiting, and abdominal pain have been reported commonly with the use of vapreotide.