Candicidine
Candicidine Uses, Dosage, Side Effects, Food Interaction and all others data.
Candicidine is an antibiotic obtained from a streptomyces (Streptomyces griseus) and active against some fungi of the genus Candida (C. albicans). Candicidine is administered intravaginally in the treatment of vulvovaginal candidiasis.
Candicidine is a polyene antifungal antibiotic produced by a strain of Streptomyces griseus. It is especially effective against Candida albicans (more effective than amphotericin B), and is administered intravaginally in the treatment of vulvovaginal candidiasis.
| Trade Name | Candicidine |
| Generic | Candicidin |
| Candicidin Other Names | Candicidin, Candicidina, Candicidine, Candicidinum, Candizidin, Levorin, Levorina, Levorine, Levorinum |
| Type | |
| Formula | C59H84N2O18 |
| Weight | Average: 1109.317 Monoisotopic: 1108.571913873 |
| Groups | Approved, Withdrawn |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Used in the topical treatment of vulvovaginal candidiasis.
How Candicidine works
Ergosterol, the principal sterol in the fungal cytoplasmic membrane, is the target site of action of Candicidine. Candicidine binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. There is some evidence that the binding site in the cell wall may be to fatty acids or fatty acid esters and that this binding capacity must be satisfied before candicidin can bring about its lethal effect by binding to sterol in the cell membrane.
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