Canfosfamide
Canfosfamide Uses, Dosage, Side Effects, Food Interaction and all others data.
Canfosfamide is an active agent in chemotherapy-resistant ovarian cancer.
Trade Name | Canfosfamide |
Generic | Canfosfamide |
Canfosfamide Other Names | Canfosfamide |
Type | |
Formula | C26H40Cl4N5O10PS |
Weight | Average: 787.46 Monoisotopic: 785.0987615 |
Groups | Investigational |
Therapeutic Class | |
Manufacturer | |
Available Country | |
Last Updated: | September 19, 2023 at 7:00 am |
Uses
Intended for the treatment of various forms of cancer.
How Canfosfamide works
S-transferase P1-1 (GST P1-1) is an enzyme overexpressed in many human cancer cells. High levels of GST P1-1 are associated with a poor prognosis and resistance to certain chemotherapeutics. The activation of canfosfamide occurs when GST P1-1 splits canfosfamide into two active fragments: a glutathione analog fragment and an active cytotoxic fragment. The cytotoxic fragment reacts with important cell components, including RNA, DNA and proteins, leading to cell death. The glutathione analog fragment of canfosfamide may remain bound to GST P1-1, which may limit the ability of GST P1-1 to inactivate other cancer drugs.
Toxicity
Canfosfamide-related toxicities included grade 1-2 nausea, vomiting, fatigue, transient microscopic hematuria, and anemia.
Half Life
18 min
Innovators Monograph
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