Canfosfamide

Canfosfamide Uses, Dosage, Side Effects, Food Interaction and all others data.

Canfosfamide is an active agent in chemotherapy-resistant ovarian cancer.

Table Of contents

• Canfosfamide
• Uses
• Dosage
• Side Effect
• Precautions
• Interactions
• Uses during Pregnancy
• Uses during Breastfeeding
• Accute Overdose
• Food Interaction
• Half Life
• Volume of Distribution
• Clearance
• Interaction With other Medicine
• Contradiction
• Storage

Trade Name	Canfosfamide
Generic	Canfosfamide
Canfosfamide Other Names	Canfosfamide
Type
Formula	C26H40Cl4N5O10PS
Weight	Average: 787.46 Monoisotopic: 785.0987615
Groups	Investigational
Therapeutic Class
Manufacturer
Available Country
Last Updated:	September 19, 2023 at 7:00 am

Uses

Intended for the treatment of various forms of cancer.

How Canfosfamide works

S-transferase P1-1 (GST P1-1) is an enzyme overexpressed in many human cancer cells. High levels of GST P1-1 are associated with a poor prognosis and resistance to certain chemotherapeutics. The activation of canfosfamide occurs when GST P1-1 splits canfosfamide into two active fragments: a glutathione analog fragment and an active cytotoxic fragment. The cytotoxic fragment reacts with important cell components, including RNA, DNA and proteins, leading to cell death. The glutathione analog fragment of canfosfamide may remain bound to GST P1-1, which may limit the ability of GST P1-1 to inactivate other cancer drugs.

Toxicity

Canfosfamide-related toxicities included grade 1-2 nausea, vomiting, fatigue, transient microscopic hematuria, and anemia.

Half Life

18 min

Innovators Monograph

You find simplified version here Canfosfamide