Chlortetracycline

Chlortetracycline Uses, Dosage, Side Effects, Food Interaction and all others data.

Chlortetracycline is a tetracycline antibiotic, and historically the first member of this class to be identified. It was discovered in 1945 by the scientist, Benjamin Minge Duggar, working at Lederle Laboratories under the supervision of Yellapragada Subbarow. He discovered that this antibiotic was the product of an actinomycete strain he cultured and obtained from a soil sample from a field in Missouri. The organism was named Streptomyces aureofaciens due to its gold-hued color.

Tetracycline antibiotics are bacteriostatic agents which act to inhibit bacterial growth and reproduction .

Chlortetracycline
Uses
Dosage
Side Effect
Precautions
Interactions
Uses during Pregnancy
Uses during Breastfeeding
Accute Overdose
Food Interaction
Half Life
Volume of Distribution
Clearance
Interaction With other Medicine
Contradiction
Storage

Trade Name	Chlortetracycline
Generic	Chlortetracycline
Chlortetracycline Other Names	Chlortetracycline, Chlortétracycline, Chlortetracyclinum, Clortetraciclina
Type
Formula	C₂₂H₂₃ClN₂O₈
Weight	Average: 478.88 Monoisotopic: 478.114293429
Protein binding	Chlortetracline is 50-55% bound to plasma proteins .
Groups	Approved, Investigational, Vet approved
Therapeutic Class
Manufacturer
Available Country
Last Updated:	September 19, 2023 at 7:00 am

Uses

Chlortetracycline is the first tetracycline antibiotic most commonly used for veterinary purposes.

Used in the manufacuring of medicated animal feeds .

Chlortetracycline is also used to associated treatment for these conditions: Eye and eyelid infections, Pyoderma, Wound Infections, Corticosteroid-responsive dermatoses

How Chlortetracycline works

Chlortetracycline, like other tetracyclines, competes for the A site of the bacterial ribosome . This binding competes with tRNA carrying amino acids preventing the addition of more amino acids to the peptide chain. This inhibition of protein synthesis ultimately inhibits growth and reproduction of the bacterial cell as necessary proteins cannot be synthesized.

Toxicity

The acute oral LD50 in mice is 2314mg/kg .The most common adverse effects of tertacylines are gastrointestinal disturbances, and staining of teeth and bone. Some occurences of dental hypoplasia and bone deformity have been noted . In pregnant women tetracyclines may produce hepatotoxicity.