Clortetraciclina
Clortetraciclina Uses, Dosage, Side Effects, Food Interaction and all others data.
Clortetraciclina is a tetracycline antibiotic, and historically the first member of this class to be identified. It was discovered in 1945 by the scientist, Benjamin Minge Duggar, working at Lederle Laboratories under the supervision of Yellapragada Subbarow. He discovered that this antibiotic was the product of an actinomycete strain he cultured and obtained from a soil sample from a field in Missouri. The organism was named Streptomyces aureofaciens due to its gold-hued color.
Tetracycline antibiotics are bacteriostatic agents which act to inhibit bacterial growth and reproduction .
Trade Name | Clortetraciclina |
Generic | Chlortetracycline |
Chlortetracycline Other Names | Chlortetracycline, Chlortétracycline, Chlortetracyclinum, Clortetraciclina |
Type | |
Formula | C22H23ClN2O8 |
Weight | Average: 478.88 Monoisotopic: 478.114293429 |
Protein binding | Chlortetracline is 50-55% bound to plasma proteins . |
Groups | Approved, Investigational, Vet approved |
Therapeutic Class | |
Manufacturer | |
Available Country | |
Last Updated: | September 19, 2023 at 7:00 am |
Uses
Clortetraciclina is the first tetracycline antibiotic most commonly used for veterinary purposes.
Used in the manufacuring of medicated animal feeds .
Clortetraciclina is also used to associated treatment for these conditions: Eye and eyelid infections, Pyoderma, Wound Infections, Corticosteroid-responsive dermatoses
How Clortetraciclina works
Clortetraciclina, like other tetracyclines, competes for the A site of the bacterial ribosome . This binding competes with tRNA carrying amino acids preventing the addition of more amino acids to the peptide chain. This inhibition of protein synthesis ultimately inhibits growth and reproduction of the bacterial cell as necessary proteins cannot be synthesized.
Toxicity
The acute oral LD50 in mice is 2314mg/kg .The most common adverse effects of tertacylines are gastrointestinal disturbances, and staining of teeth and bone. Some occurences of dental hypoplasia and bone deformity have been noted . In pregnant women tetracyclines may produce hepatotoxicity.
Food Interaction
No interactions found.Volume of Distribution
Clortetraciclina has a volume of distribution of 100 liters .
Elimination Route
Chortetracycline reaches peak plasma concentation in about 3 hours . Its oral bioavailability is 25-30%.
Half Life
The half-life of Clortetraciclina is 5.6 hours .
Elimination Route
Clortetraciclina is mainly eliminated in feces . Renal function does not appear to affect the rate of elimination.
Innovators Monograph
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