Chromium Chloride Uses, Dosage, Side Effects and more
Chromium Chloride, for injection, is a sterile, nonpyrogenic solution intended for use as an additive to solutions for Total Parenteral Nutrition (TPN).
Trivalent chromium is part of glucose tolerance factor, an essential activator of insulin-mediated reactions. Chromium helps to maintain normal glucose metabolism and peripheral nerve function. Providing chromium during TPN helps prevent deficiency symptoms including impaired glucose tolerance, ataxia, peripheral neuropathy and a confusional state similar to mild/moderate hepatic encephalopathy.
| Trade Name | Chromium Chloride |
| Generic | Chromic chloride |
| Chromic chloride Other Names | Chromium chloride, Chromium trichloride, chromium(3+) trichloride, Chromium(III) chloride, Puratronic chromium chloride, Trichlorochromium |
| Type | |
| Formula | Cl3Cr |
| Weight | Average: 158.355 Monoisotopic: 156.847070025 |
| Protein binding | Chromic chloride-induced binding of protein to red cells. |
| Groups | Approved |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | January 7, 2025 at 1:49 am |
Uses
Chromium Chloride is a supplement to intravenous solutions given for total parenteral nutrition (TPN).
For use as a supplement to intravenous solutions given for total parenteral nutrition (TPN).
Chromium Chloride is also used to associated treatment for these conditions: Total parenteral nutrition therapy
How Chromium Chloride works
Metallic chromium has no biological activity. Chromium is referred as a glucose tolerance factor. This glucose tolerance factor is a complex of molecules. Glycine, cysteine, glutamic acid and nicotinic acid along with chromium form this complex.
Toxicity
Reported toxic reactions to chromium include nausea, vomiting, ulcers of the gastrointestinal tract, renal and hepatic damage, convulsions and coma. The acute LD50 for intravenous trivalent chromium in rats was reported as 10 to 18 mg/kg.
Food Interaction
- Administer vitamin supplements. Niacin (from food or supplements) may increase the absorption of chromium.
- Take with foods containing vitamin C. Vitamin C may increase the oral absorption of chromium/chromic chloride.
Volume of Distribution
Chromium is stored in liver, spleen, soft tissue and bone.
Elimination Route
Chromium absorption can increase with exercise.
Half Life
31- 41 hours
Elimination Route
Most absorbed chromium is excreted rapidly in the urine, whereas unabsorbed chromium is excreted through feces.
