Chromium(3+) Trichloride

Chromium(3+) Trichloride Uses, Dosage, Side Effects, Food Interaction and all others data.

Chromium(3+) Trichloride, for injection, is a sterile, nonpyrogenic solution intended for use as an additive to solutions for Total Parenteral Nutrition (TPN).

Trivalent chromium is part of glucose tolerance factor, an essential activator of insulin-mediated reactions. Chromium helps to maintain normal glucose metabolism and peripheral nerve function. Providing chromium during TPN helps prevent deficiency symptoms including impaired glucose tolerance, ataxia, peripheral neuropathy and a confusional state similar to mild/moderate hepatic encephalopathy.

Table Of contents

• Chromium(3+) Trichloride
• Uses
• Dosage
• Side Effect
• Precautions
• Interactions
• Uses during Pregnancy
• Uses during Breastfeeding
• Accute Overdose
• Food Interaction
• Half Life
• Volume of Distribution
• Clearance
• Interaction With other Medicine
• Contradiction
• Storage

Trade Name	Chromium(3+) Trichloride
Generic	Chromic chloride
Chromic chloride Other Names	Chromium chloride, Chromium trichloride, chromium(3+) trichloride, Chromium(III) chloride, Puratronic chromium chloride, Trichlorochromium
Type
Formula	Cl3Cr
Weight	Average: 158.355 Monoisotopic: 156.847070025
Protein binding	Chromic chloride-induced binding of protein to red cells.
Groups	Approved
Therapeutic Class
Manufacturer
Available Country
Last Updated:	September 19, 2023 at 7:00 am

Uses

Chromium(3+) Trichloride is a supplement to intravenous solutions given for total parenteral nutrition (TPN).

For use as a supplement to intravenous solutions given for total parenteral nutrition (TPN).

Chromium(3+) Trichloride is also used to associated treatment for these conditions: Total parenteral nutrition therapy

How Chromium(3+) Trichloride works

Metallic chromium has no biological activity. Chromium is referred as a glucose tolerance factor. This glucose tolerance factor is a complex of molecules. Glycine, cysteine, glutamic acid and nicotinic acid along with chromium form this complex.

Toxicity

Reported toxic reactions to chromium include nausea, vomiting, ulcers of the gastrointestinal tract, renal and hepatic damage, convulsions and coma. The acute LD50 for intravenous trivalent chromium in rats was reported as 10 to 18 mg/kg.

Food Interaction

• Administer vitamin supplements. Niacin (from food or supplements) may increase the absorption of chromium.
• Take with foods containing vitamin C. Vitamin C may increase the oral absorption of chromium/chromic chloride.

Volume of Distribution

Chromium is stored in liver, spleen, soft tissue and bone.

Elimination Route

Chromium absorption can increase with exercise.

Half Life

31- 41 hours

Elimination Route

Most absorbed chromium is excreted rapidly in the urine, whereas unabsorbed chromium is excreted through feces.

Innovators Monograph

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