Céfalotine

Céfalotine Uses, Dosage, Side Effects, Food Interaction and all others data.

Céfalotine is a cephalosporin antibiotic.

Céfalotine (INN) or cephalothin (USAN) is a semisynthetic first generation cephalosporin having a broad spectrum of antibiotic activity that is administered parenterally.

Table Of contents

• Céfalotine
• Uses
• Dosage
• Side Effect
• Precautions
• Interactions
• Uses during Pregnancy
• Uses during Breastfeeding
• Accute Overdose
• Food Interaction
• Half Life
• Volume of Distribution
• Clearance
• Interaction With other Medicine
• Contradiction
• Storage

Trade Name	Céfalotine
Generic	Cefalotin
Cefalotin Other Names	Cefalothin, Cefalotin, Cefalotina, Céfalotine, Cefalotinum, Cephalothin, Cephalotin
Type
Formula	C16H16N2O6S2
Weight	Average: 396.438 Monoisotopic: 396.044977634
Protein binding	65-80%
Groups	Approved, Investigational, Vet approved
Therapeutic Class
Manufacturer
Available Country
Last Updated:	September 19, 2023 at 7:00 am

Uses

Céfalotine is a broad-spectrum cephalosporin antibiotic used for the treatment of serious bacterial infections in various locations, such as the urinary tract, skin, bone, and lower respiratory tract.

Used to prevent infection during surgery and to treat many kinds of infections of the blood, bone or joints, respiratory tract, skin, and urinary tract.

Céfalotine is also used to associated treatment for these conditions: Susceptible Bacterial Infections

How Céfalotine works

The bactericidal activity of cefalotin results from the inhibition of cell wall synthesis via affinity for penicillin-binding proteins (PBPs). The PBPs are transpeptidases which are vital in peptidoglycan biosynthesis. Therefore, their inhibition prevents this vital cell wall compenent from being properly synthesized.

Toxicity

Rat intravenous LD₅₀ is 4000 mg/kg.

Food Interaction

No interactions found.

Half Life

30 minutes

Innovators Monograph

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