Diethylamino hydroxybenzoyl hexyl benzoate
Diethylamino hydroxybenzoyl hexyl benzoate Uses, Dosage, Side Effects, Food Interaction and all others data.
Diethylamino hydroxybenzoyl hexyl benzoate is a UV filter with high absorption in the UV-A range. Minimizing the overexposure of human skin to ultraviolet radiation that may lead to acute and chronic photodamage, diethylamino hydroxybenzoyl hexyl benzoate is an oil-soluble UV filter that may be incorporated in the oil phase of emulsions . Diethylamino hydroxybenzoyl hexyl benzoate was approved in Europe in 2005, and is also marketed in the U.S., South America, Mexico, Japan and Taiwan. It has a chemical structure similar to the classical benxophoenone drug class, and displays good photostability . It is used in concentrations up to 10% in sunscreen products, either alone or in combination with other UV absorbers .
Diethylamino hydroxybenzoyl hexyl benzoate is an organic UV filter that attenuates the exposure of UV radiation on human skin . In vitro, topical application of diethylamino hydroxybenzoyl hexyl benzoate exerted an anti-inflammatory effect on inflammation-evoked mouse ears by inhibiting oedema formation .
| Trade Name | Diethylamino hydroxybenzoyl hexyl benzoate |
| Generic | Diethylamino hydroxybenzoyl hexyl benzoate |
| Type | |
| Formula | C24H31NO4 |
| Weight | Average: 397.515 Monoisotopic: 397.225308482 |
| Protein binding | No pharmacokinetic data. |
| Groups | Approved |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Indicated for use as a sunscreen agent.
Diethylamino hydroxybenzoyl hexyl benzoate is also used to associated treatment for these conditions: Sunburn
How Diethylamino hydroxybenzoyl hexyl benzoate works
Diethylamino hydroxybenzoyl hexyl benzoate absorbs in the UV-A range with the peak at 354 nm .
Toxicity
In a rat acute oral toxicity study, median LD50 value was reported to be >2000 mg/kg . No case of overdose has been reported. Diethylamino hydroxybenzoyl hexyl benzoate was not shown to be mutagenic, clastogenic, or phototoxic in vitro . The no observed adverse effect level (NOAEL) 200 mg/kg bw/day for maternal toxicity, and 1000 mg/kg bw/day (highest applied dose) for prenatal developmental toxicity .
Food Interaction
No interactions found.Volume of Distribution
No pharmacokinetic data.
Elimination Route
Based on the findings of a rat study assessing dermal or percutaneous absorption, only a minor amount of diethylamino hydroxybenzoyl hexyl benzoate will undergo percutaneous absorption and most of the compounds will remain in the upper layers of the stratum corneum . In rat and porcine skin, the percutaneous absorption was 0.10 ± 0.12 μg/cm^2 or 0.04 ± 0.05% .
Half Life
No pharmacokinetic data.
Clearance
No pharmacokinetic data.
Elimination Route
No pharmacokinetic data.
Innovators Monograph
You find simplified version here Diethylamino hydroxybenzoyl hexyl benzoate
