Diethylamino hydroxybenzoyl hexyl benzoate

Diethylamino hydroxybenzoyl hexyl benzoate Uses, Dosage, Side Effects, Food Interaction and all others data.

Diethylamino hydroxybenzoyl hexyl benzoate is a UV filter with high absorption in the UV-A range. Minimizing the overexposure of human skin to ultraviolet radiation that may lead to acute and chronic photodamage, diethylamino hydroxybenzoyl hexyl benzoate is an oil-soluble UV filter that may be incorporated in the oil phase of emulsions . Diethylamino hydroxybenzoyl hexyl benzoate was approved in Europe in 2005, and is also marketed in the U.S., South America, Mexico, Japan and Taiwan. It has a chemical structure similar to the classical benxophoenone drug class, and displays good photostability . It is used in concentrations up to 10% in sunscreen products, either alone or in combination with other UV absorbers .

Diethylamino hydroxybenzoyl hexyl benzoate is an organic UV filter that attenuates the exposure of UV radiation on human skin . In vitro, topical application of diethylamino hydroxybenzoyl hexyl benzoate exerted an anti-inflammatory effect on inflammation-evoked mouse ears by inhibiting oedema formation .

Trade Name Diethylamino hydroxybenzoyl hexyl benzoate
Generic Diethylamino hydroxybenzoyl hexyl benzoate
Type
Formula C24H31NO4
Weight Average: 397.515
Monoisotopic: 397.225308482
Protein binding

No pharmacokinetic data.

Groups Approved
Therapeutic Class
Manufacturer
Available Country
Last Updated: September 19, 2023 at 7:00 am
Diethylamino hydroxybenzoyl hexyl benzoate
Diethylamino hydroxybenzoyl hexyl benzoate

Uses

Indicated for use as a sunscreen agent.

Diethylamino hydroxybenzoyl hexyl benzoate is also used to associated treatment for these conditions: Sunburn

How Diethylamino hydroxybenzoyl hexyl benzoate works

Diethylamino hydroxybenzoyl hexyl benzoate absorbs in the UV-A range with the peak at 354 nm .

Toxicity

In a rat acute oral toxicity study, median LD50 value was reported to be >2000 mg/kg . No case of overdose has been reported. Diethylamino hydroxybenzoyl hexyl benzoate was not shown to be mutagenic, clastogenic, or phototoxic in vitro . The no observed adverse effect level (NOAEL) 200 mg/kg bw/day for maternal toxicity, and 1000 mg/kg bw/day (highest applied dose) for prenatal developmental toxicity .

Food Interaction

No interactions found.

Volume of Distribution

No pharmacokinetic data.

Elimination Route

Based on the findings of a rat study assessing dermal or percutaneous absorption, only a minor amount of diethylamino hydroxybenzoyl hexyl benzoate will undergo percutaneous absorption and most of the compounds will remain in the upper layers of the stratum corneum . In rat and porcine skin, the percutaneous absorption was 0.10 ± 0.12 μg/cm^2 or 0.04 ± 0.05% .

Half Life

No pharmacokinetic data.

Clearance

No pharmacokinetic data.

Elimination Route

No pharmacokinetic data.

Innovators Monograph

You find simplified version here Diethylamino hydroxybenzoyl hexyl benzoate

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