Dimetil Sulfóxido

Dimetil Sulfóxido Uses, Dosage, Side Effects, Food Interaction and all others data.

A highly polar organic liquid, that is used widely as a chemical solvent. Because of its ability to penetrate biological membranes, it is used as a vehicle for topical application of pharmaceuticals. It is also used to protect tissue during cryopreservation. Dimetil Sulfóxido shows a range of pharmacological activity including analgesia and anti-inflammation.

Dimethyl Sulfoxide may have anti-inflammatory, antioxidant and analgesic activities. Dimethyl Sulfoxide also readily penetrates cellular membranes. The membrane-penetrating ability of dimethyl sulfoxide may enhance diffusion of other substances through the skin. For this reason, mixtures of idoxuridine and dimethyl sulfoxide have been used for topical treatment of herpes zoster in the United Kingdom.

Trade Name Dimetil Sulfóxido
Generic Dimethyl sulfoxide
Dimethyl sulfoxide Other Names Dimethyl sulfoxide, Dimethyl sulfur oxide, Dimethyl sulphoxide, Dimethyli sulfoxidum, Dimethylsulfoxid, Diméthylsulfoxyde, Dimetil sulfóxido, DMSO, Methylsulfinylmethane
Type
Formula C2H6OS
Weight Average: 78.133
Monoisotopic: 78.013935504
Groups Approved, Vet approved
Therapeutic Class
Manufacturer
Available Country
Last Updated: September 19, 2023 at 7:00 am
Dimetil Sulfóxido
Dimetil Sulfóxido

Uses

Dimetil Sulfóxido is a reversible mitogen-activated extracellular signal-regulated kinase-1 (MEK1) and MEK2 inhibitor used to treat certain types of melanoma, metastatic non-small cell lung cancer, and locally advanced or metastatic anaplastic thyroid cancer.

For the symptomatic relief of patients with interstitial cystitis.

Dimetil Sulfóxido is also used to associated treatment for these conditions: Interstitial Cystitis, Extravasation of chemotherapy drugs

How Dimetil Sulfóxido works

The mechanism of dimethyl sulfoxide's actions is not well understood. Dimetil Sulfóxido has demonstrated antioxidant activity in certain biological settings. For example, the cardiovascular protective effect of dimethyl sulfoxide in copper-deficient rats is thought to occur by an antioxidant mechanism. It is also thought that dimethyl sulfoxide's possible anti-inflammatory activity is due to antioxidant action.

Toxicity

The oral LD50 of dimethyl sulfoxide in the dog is greater than 10 gm/kg. It is improbable that this dosage level could be obtained with intravesical instillation of dimethyl sulfoxide in the patient.

Food Interaction

No interactions found.

Elimination Route

Readily and rapidly absorbed following administration by all routes and distributed throughout the body.

Elimination Route

Dimetil Sulfóxido and dimethyl sulfone are excreted in the urine and feces.

Innovators Monograph

You find simplified version here Dimetil Sulfóxido

*** Taking medicines without doctor's advice can cause long-term problems.
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