(E)-metanicotine

(E)-metanicotine Uses, Dosage, Side Effects, Food Interaction and all others data.

(E)-metanicotine (TC-2403, RJR-2403, (E)-metanicotine) is a partial agonist at neuronal nicotinic acetylcholine receptors, binding primarily to the α4β2 subtype. It was originally developed as a potential treatment for Alzheimer's disease for its nootropic effects but has also been found to inhibit the production of Interleukin-8. It has subsequently been developed as a potential anti-inflammatory treatment for ulcerative colitis. (E)-metanicotine also has stimulant and analgesic actions which are thought due to increased noradrenaline release.

Table Of contents

• (E)-metanicotine
• Uses
• Dosage
• Side Effect
• Precautions
• Interactions
• Uses during Pregnancy
• Uses during Breastfeeding
• Accute Overdose
• Food Interaction
• Half Life
• Volume of Distribution
• Clearance
• Interaction With other Medicine
• Contradiction
• Storage

Trade Name	(E)-metanicotine
Generic	Rivanicline
Rivanicline Other Names	(E)-metanicotine, Rivanicline, trans-metanicotine
Type
Formula	C10H14N2
Weight	Average: 162.2316 Monoisotopic: 162.115698458
Groups	Investigational
Therapeutic Class
Manufacturer
Available Country
Last Updated:	September 19, 2023 at 7:00 am

Uses

Investigated for use/treatment in ulcerative colitis.

How (E)-metanicotine works

(E)-metanicotine is a (E)-metanicotine hemigalactarate. It effectively inhibits TNF- and LPS-induced IL-8 production in different cell types.

Innovators Monograph

You find simplified version here (E)-metanicotine