Trans-metanicotine

Trans-metanicotine Uses, Dosage, Side Effects, Food Interaction and all others data.

Trans-metanicotine (TC-2403, RJR-2403, (E)-metanicotine) is a partial agonist at neuronal nicotinic acetylcholine receptors, binding primarily to the α4β2 subtype. It was originally developed as a potential treatment for Alzheimer's disease for its nootropic effects but has also been found to inhibit the production of Interleukin-8. It has subsequently been developed as a potential anti-inflammatory treatment for ulcerative colitis. Trans-metanicotine also has stimulant and analgesic actions which are thought due to increased noradrenaline release.

Trade Name Trans-metanicotine
Generic Rivanicline
Rivanicline Other Names (E)-metanicotine, Rivanicline, trans-metanicotine
Type
Formula C10H14N2
Weight Average: 162.2316
Monoisotopic: 162.115698458
Groups Investigational
Therapeutic Class
Manufacturer
Available Country
Last Updated: September 19, 2023 at 7:00 am
Trans-metanicotine
Trans-metanicotine

Uses

Investigated for use/treatment in ulcerative colitis.

How Trans-metanicotine works

Trans-metanicotine is a (E)-metanicotine hemigalactarate. It effectively inhibits TNF- and LPS-induced IL-8 production in different cell types.

Innovators Monograph

You find simplified version here Trans-metanicotine

*** Taking medicines without doctor's advice can cause long-term problems.
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