Ecamsule
Ecamsule Uses, Dosage, Side Effects, Food Interaction and all others data.
Ecamsule is an organic compound which is added to many sunscreens to filter out UVA rays. It is a benzylidene camphor derivative, many of which are known for their excellent photostability. Ecamsule has been approved for use in the U.S. since 2006, but only at a specific concentration and only in a few products manufactured by L'Oreal. The company got approval for those products through a new drug application process.
When exposed to UV ecamsule undergoes reversible photoisomerization followed by photoexcitation. The absorbed UV is then released as thermal energy, without penetrating the skin, thereby protecting the skin from UV exposure.
Trade Name | Ecamsule |
Generic | Ecamsule |
Ecamsule Other Names | Ecamsule, Terephthalylidene dicamphor sulfonic acid |
Type | |
Formula | C28H34O8S2 |
Weight | Average: 562.69 Monoisotopic: 562.169510403 |
Protein binding | Ecamsule is intended for topical application only. |
Groups | Approved |
Therapeutic Class | |
Manufacturer | |
Available Country | |
Last Updated: | September 19, 2023 at 7:00 am |
Uses
Ecamsule is a sunscreen agent found in sunscreens that absorbs UV rays.
Applied topically to filter out UVA rays.
Ecamsule is also used to associated treatment for these conditions: Sunburn
How Ecamsule works
Ecamsule protects against UV wavelengths in the 290–400 nanometer range, with peak protection at 345 nm. Ecamsule is photostable and it does not degrade significantly when exposed to light. In studies done in mice it reduces the formation of UV induced pyrimidine dimers and delays the onset of skin cancer. In vitro, ecamsule has been shown to effectively protect against the harmful effects of UV.
Toxicity
The most common reactions were dermatitis, dry skin, acne, itching, redness and skin discomfort.
Food Interaction
No interactions found.Volume of Distribution
Ecamsule is intended for topical application and has no volume of distribution.
Elimination Route
Ecamsule is a topical preparation, it should not be absorbed. Research done by L'Oreal on human subjects revealed that the systemically absorbed dose of [(14)C]-Ecamsule is less than 0.1% and under realistic exposure conditions, the human systemic exposure to this UVA filter is negligible and poses no risk to human health.
Half Life
Ecamsule is not absorbed and has no reported half life data.
Clearance
Ecamsule is used topically, it not absorbed or metabolized.
Elimination Route
Ecamsule is intended for topical application only.
Innovators Monograph
You find simplified version here Ecamsule