Terephthalylidene Dicamphor Sulfonic Acid

Terephthalylidene Dicamphor Sulfonic Acid Uses, Dosage, Side Effects, Food Interaction and all others data.

Terephthalylidene Dicamphor Sulfonic Acid is an organic compound which is added to many sunscreens to filter out UVA rays. It is a benzylidene camphor derivative, many of which are known for their excellent photostability. Terephthalylidene Dicamphor Sulfonic Acid has been approved for use in the U.S. since 2006, but only at a specific concentration and only in a few products manufactured by L'Oreal. The company got approval for those products through a new drug application process.

When exposed to UV ecamsule undergoes reversible photoisomerization followed by photoexcitation. The absorbed UV is then released as thermal energy, without penetrating the skin, thereby protecting the skin from UV exposure.

Terephthalylidene Dicamphor Sulfonic Acid
Uses
Dosage
Side Effect
Precautions
Interactions
Uses during Pregnancy
Uses during Breastfeeding
Accute Overdose
Food Interaction
Half Life
Volume of Distribution
Clearance
Interaction With other Medicine
Contradiction
Storage

Trade Name	Terephthalylidene Dicamphor Sulfonic Acid
Generic	Ecamsule
Ecamsule Other Names	Ecamsule, Terephthalylidene dicamphor sulfonic acid
Type
Formula	C₂₈H₃₄O₈S₂
Weight	Average: 562.69 Monoisotopic: 562.169510403
Protein binding	Ecamsule is intended for topical application only.
Groups	Approved
Therapeutic Class
Manufacturer
Available Country
Last Updated:	September 19, 2023 at 7:00 am

Uses

Terephthalylidene Dicamphor Sulfonic Acid is a sunscreen agent found in sunscreens that absorbs UV rays.

Applied topically to filter out UVA rays.

Terephthalylidene Dicamphor Sulfonic Acid is also used to associated treatment for these conditions: Sunburn

How Terephthalylidene Dicamphor Sulfonic Acid works

Terephthalylidene Dicamphor Sulfonic Acid protects against UV wavelengths in the 290–400 nanometer range, with peak protection at 345 nm. Terephthalylidene Dicamphor Sulfonic Acid is photostable and it does not degrade significantly when exposed to light. In studies done in mice it reduces the formation of UV induced pyrimidine dimers and delays the onset of skin cancer. In vitro, ecamsule has been shown to effectively protect against the harmful effects of UV.

Toxicity

The most common reactions were dermatitis, dry skin, acne, itching, redness and skin discomfort.

Food Interaction

No interactions found.

Volume of Distribution

Terephthalylidene Dicamphor Sulfonic Acid is intended for topical application and has no volume of distribution.

Elimination Route

Terephthalylidene Dicamphor Sulfonic Acid is a topical preparation, it should not be absorbed. Research done by L'Oreal on human subjects revealed that the systemically absorbed dose of [(14)C]-Terephthalylidene Dicamphor Sulfonic Acid is less than 0.1% and under realistic exposure conditions, the human systemic exposure to this UVA filter is negligible and poses no risk to human health.