Erythritol Tetranitrate

Erythritol Tetranitrate Uses, Dosage, Side Effects, Food Interaction and all others data.

A vasodilator with general properties similar to nitroglycerin. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1020)

Erythrityl Tetranitrate is a vasodilator with general properties similar to nitroglycerin.

Erythritol Tetranitrate
Uses
Dosage
Side Effect
Precautions
Interactions
Uses during Pregnancy
Uses during Breastfeeding
Accute Overdose
Food Interaction
Half Life
Volume of Distribution
Clearance
Interaction With other Medicine
Contradiction
Storage

Trade Name	Erythritol Tetranitrate
Generic	Erythrityl tetranitrate
Erythrityl tetranitrate Other Names	Eritrityl tetranitrate, Eritrityli tetranitras, Erythritol tetranitrate, Erythrityl tetranitrate, Erythrol tetranitrate, Meso-erythritol tetranitrate, Tetranitrate d'eritrityle, Tetranitrato de eritritilo, Tetranitrin, Tetranitrol
Type
Formula	C₄H₆N₄O₁₂
Weight	Average: 302.11 Monoisotopic: 301.998221676
Groups	Approved, Experimental, Investigational
Therapeutic Class
Manufacturer
Available Country
Last Updated:	September 19, 2023 at 7:00 am

Uses

For the prevention of angina.

How Erythritol Tetranitrate works

Similar to other nitrites and organic nitrates, erythrityl tetranitrate is converted to an active intermediate compound which activates the enzyme guanylate cyclase. This stimulates the synthesis of cyclic guanosine 3',5'-monophosphate (cGMP) which then activates a series of protein kinase-dependent phosphorylations in the smooth muscle cells, eventually resulting in the dephosphorylation of the myosin light chain of the smooth muscle fiber. The subsequent release of calcium ions results in the relaxation of the smooth muscle cells and vasodilation.

Toxicity

Symptoms of overdose include increased intracranial pressure, with any or all of persistent throbbing headache, confusion, and moderate fever; Vertigo; Palpitations; Visual disturbances; Nausea and vomiting (possibly with colic and even bloody diarrhea); Syncope (especially in the upright posture); Air hunger and dyspnea, later followed by reduced ventilatory effort; Diaphoresis, with the skin either flushed or cold and clammy; Heart block and bradycardia; Paralysis; Coma; Seizures; Death.