Tetranitrol
Tetranitrol Uses, Dosage, Side Effects, Food Interaction and all others data.
A vasodilator with general properties similar to nitroglycerin. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1020)
Erythrityl Tetranitrate is a vasodilator with general properties similar to nitroglycerin.
| Trade Name | Tetranitrol |
| Generic | Erythrityl tetranitrate |
| Erythrityl tetranitrate Other Names | Eritrityl tetranitrate, Eritrityli tetranitras, Erythritol tetranitrate, Erythrityl tetranitrate, Erythrol tetranitrate, Meso-erythritol tetranitrate, Tetranitrate d'eritrityle, Tetranitrato de eritritilo, Tetranitrin, Tetranitrol |
| Type | |
| Formula | C4H6N4O12 |
| Weight | Average: 302.11 Monoisotopic: 301.998221676 |
| Groups | Approved, Experimental, Investigational |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
For the prevention of angina.
How Tetranitrol works
Similar to other nitrites and organic nitrates, erythrityl tetranitrate is converted to an active intermediate compound which activates the enzyme guanylate cyclase. This stimulates the synthesis of cyclic guanosine 3',5'-monophosphate (cGMP) which then activates a series of protein kinase-dependent phosphorylations in the smooth muscle cells, eventually resulting in the dephosphorylation of the myosin light chain of the smooth muscle fiber. The subsequent release of calcium ions results in the relaxation of the smooth muscle cells and vasodilation.
Toxicity
Symptoms of overdose include increased intracranial pressure, with any or all of persistent throbbing headache, confusion, and moderate fever; Vertigo; Palpitations; Visual disturbances; Nausea and vomiting (possibly with colic and even bloody diarrhea); Syncope (especially in the upright posture); Air hunger and dyspnea, later followed by reduced ventilatory effort; Diaphoresis, with the skin either flushed or cold and clammy; Heart block and bradycardia; Paralysis; Coma; Seizures; Death.
Food Interaction
- Avoid alcohol.
- Take on an empty stomach. Take at least 1 hour before or 2 hours after meals.
Innovators Monograph
You find simplified version here Tetranitrol
