Tetranitrol

Tetranitrol Uses, Dosage, Side Effects, Food Interaction and all others data.

A vasodilator with general properties similar to nitroglycerin. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1020)

Erythrityl Tetranitrate is a vasodilator with general properties similar to nitroglycerin.

Trade Name Tetranitrol
Generic Erythrityl tetranitrate
Erythrityl tetranitrate Other Names Eritrityl tetranitrate, Eritrityli tetranitras, Erythritol tetranitrate, Erythrityl tetranitrate, Erythrol tetranitrate, Meso-erythritol tetranitrate, Tetranitrate d'eritrityle, Tetranitrato de eritritilo, Tetranitrin, Tetranitrol
Type
Formula C4H6N4O12
Weight Average: 302.11
Monoisotopic: 301.998221676
Groups Approved, Experimental, Investigational
Therapeutic Class
Manufacturer
Available Country
Last Updated: September 19, 2023 at 7:00 am
Tetranitrol
Tetranitrol

Uses

For the prevention of angina.

How Tetranitrol works

Similar to other nitrites and organic nitrates, erythrityl tetranitrate is converted to an active intermediate compound which activates the enzyme guanylate cyclase. This stimulates the synthesis of cyclic guanosine 3',5'-monophosphate (cGMP) which then activates a series of protein kinase-dependent phosphorylations in the smooth muscle cells, eventually resulting in the dephosphorylation of the myosin light chain of the smooth muscle fiber. The subsequent release of calcium ions results in the relaxation of the smooth muscle cells and vasodilation.

Toxicity

Symptoms of overdose include increased intracranial pressure, with any or all of persistent throbbing headache, confusion, and moderate fever; Vertigo; Palpitations; Visual disturbances; Nausea and vomiting (possibly with colic and even bloody diarrhea); Syncope (especially in the upright posture); Air hunger and dyspnea, later followed by reduced ventilatory effort; Diaphoresis, with the skin either flushed or cold and clammy; Heart block and bradycardia; Paralysis; Coma; Seizures; Death.

Food Interaction

  • Avoid alcohol.
  • Take on an empty stomach. Take at least 1 hour before or 2 hours after meals.

Innovators Monograph

You find simplified version here Tetranitrol

*** Taking medicines without doctor's advice can cause long-term problems.
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