Estrone Monooleate
Estrone Monooleate Uses, Dosage, Side Effects, Food Interaction and all others data.
Estrone Monooleate (OE) is a fatty acid ester of estrone. This hormone occurs naturally and is found circulating in various animal species and humans. It has been shown in animal studies to promote the loss of body fat while maintaining body protein storage, maintaining nitrogen balance. Body protein loss is an unpleasant effect of fat loss by the restriction of calories, and studies show that this drug appears to avoid this effect.
Estrone Monooleate is a fatty acid ester of estrone, and may be directly involved in the control of body weight (PMID: 8782737).
| Trade Name | Estrone Monooleate |
| Generic | Oleoyl-estrone |
| Oleoyl-estrone Other Names | Estrone monooleate, Estrone oleic acid ester, Oleoyl estrone, Oleoylestrone |
| Type | |
| Formula | C36H54O3 |
| Weight | Average: 534.8122 Monoisotopic: 534.407295594 |
| Groups | Investigational |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
For the treatment of obesity.
How Estrone Monooleate works
Based on extensive preclinical studies, it is believed that oleoyl-estrone (OE) works by a dual mechanism of action. Centrally, OE appears to act at the brain's hypothalamus, resetting the body's ponderostat, the “food control center” in the brain that detects and integrates signals that control both appetite and metabolic behavior. Peripherally, OE also causes reduced storage of fat in “white fat” tissue and allows skeletal muscle to use fat as an alternate energy source.
Elimination Route
Orally available
Innovators Monograph
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