Gabapentinum Enacarbilum
Gabapentinum Enacarbilum Uses, Dosage, Side Effects, Food Interaction and all others data.
Gabapentinum Enacarbilum is marketed under the name Horizant. It is a prodrug of gabapentin, and indicated in adults for the treatment of Restless Legs Syndrome (RLS) and postherpetic neuralgia (PHN).
Since gabapentin enacarbil is a prodrug of gabapentin, it's physiological effects are the same as gabapentin. Concerning PHN, gabapentin prevents allodynia and hyperalgesia.
Trade Name | Gabapentinum Enacarbilum |
Generic | Gabapentin enacarbil |
Gabapentin enacarbil Other Names | Gabapentin enacarbil, Gabapentina enacarbilo, Gabapentine enacarbil, Gabapentinum enacarbilum |
Type | |
Formula | C16H27NO6 |
Weight | Average: 329.393 Monoisotopic: 329.183837593 |
Protein binding | Gabapentin plasma protein binding is less than 3%. |
Groups | Approved, Investigational |
Therapeutic Class | |
Manufacturer | |
Available Country | |
Last Updated: | September 19, 2023 at 7:00 am |
Uses
Gabapentinum Enacarbilum is a gabapentin prodrug used to treat Restless Legs Syndrome (RLS) and postherpetic neuralgia (PHN).
For the treatment of adult Restless Legs Syndrome (RLS) and postherpetic neuralgia (PHN).
Gabapentinum Enacarbilum is also used to associated treatment for these conditions: Post-Herpetic Neuralgia (PHN), Restless Legs Syndrome (RLS)
How Gabapentinum Enacarbilum works
Although the exact mechanism of action of gabapentin in RLS and PHN is unknown, it is presumed to involve the descending noradrenergic system, resulting in the activation of spinal alpha2-adrenergic receptors.
Toxicity
Most common adverse reactions are headache, dizziness, and somnolence.
Food Interaction
- Take with or without food.
Volume of Distribution
The volume of distribution is 76L.
Elimination Route
Gabapentinum Enacarbilum is absorbed in the intestines by active transport through the proton-linked monocarboxylate transporter, MCT-1.
Half Life
The elimination half-life of gabapentin is 5.1 to 6.0 hours.
Clearance
Renal clearance of gabapentin is 5 to 7 L/hr.
Elimination Route
Gabapentinum Enacarbilum is eliminated primarily in the urine (94%) and to a lesser extent in the feces (5%).
Innovators Monograph
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