GenESA

GenESA Uses, Dosage, Side Effects, Food Interaction and all others data.

GenESA, administered through a closed-loop, computer-controlled drug-delivery system, is indicated to elicit acute cardiovascular responses, similar to those produced by exercise, in order to aid in diagnosing the presence or absence of coronary artery disease in patients who cannot exercise adequately .

Trade Name GenESA
Availability Discontinued
Generic Arbutamine
Arbutamine Other Names Arbutamina, Arbutamine, Arbutaminum
Type
Formula C18H23NO4
Weight Average: 317.3795
Monoisotopic: 317.162708229
Protein binding

58%

Groups Approved
Therapeutic Class
Manufacturer
Available Country
Last Updated: September 19, 2023 at 7:00 am
GenESA
GenESA

Uses

Used to elicit acute cardiovascular responses (cardiac stumulant), similar to those produced by exercise, in order to aid in diagnosing the presence or absence of coronary artery disease (CAD) in patients who cannot exercise adequately.

How GenESA works

GenESA is a synthetic catecholamine with positive chronotropic and inotropic properties. The chronotropic (increase in heart rate) and inotropic (increase in force of contraction) effects of arbutamine serve to mimic exercise by increasing cardiac work (producing stress) and provoke myocardial ischemia in patients with compromised coronary arteries. The increase in heart rate caused by arbutamine is thought to limit regional subendocardial perfusion, thereby limiting tissue oxygenation. In functional assays, arbutamine is more selective for beta-adrenergic receptors than for alpha-adrenergic receptors. The beta-agonist activity of arbutamine provides cardiac stress by increasing heart rate, cardiac contractility, and systolic blood pressure. The degree of hypotension that occurs for a given chronotropic activity is less with arbutamine than, for example, with isoproterenol because alpha receptor activity is retained.

GenESA Hypertension interaction

[Major] Dobutamine and arbutamine produce stimulation of the beta receptors of the heart.

The use of these agents has been associated with an increase in heart rate, ventricular ectopy, atrial fibrillation, hypertension, enhanced A-V conduction, and arrhythmias.

Therapy with dobutamine or arbutamine should be administered cautiously in patients with cardiac conduction disorders.

GenESA Disease Interaction

Major: arrhythmias, hypotension, IHSS

Half Life

Elimination half-life is approximately 8 minutes.

Innovators Monograph

You find simplified version here GenESA

*** Taking medicines without doctor's advice can cause long-term problems.
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