HE3286
HE3286 Uses, Dosage, Side Effects, Food Interaction and all others data.
| Trade Name | HE3286 |
| Generic | HE3286 |
| Type | |
| Formula | C21H30O3 |
| Weight | Average: 330.468 Monoisotopic: 330.219494826 |
| Groups | Investigational |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
For the treatment of rheumatoid arthritis and type 2 diabetes.
How HE3286 works
Potential mechanisms of action for HE3286 include regulation of NF-kB and increasing the production of regulatory T cells (Treg cells). NF-kB is a well-known transcription factor that controls the production of inflammatory cytokines such as TNF-a and interferon-g. Treg cells are referred to in the scientific literature as the peacekeepers of the body. Their role is to keep the immune system from attacking the body itself. Recent studies of Treg cells indicate that they may play a broader role than simply preventing autoimmune conditions. Manipulation of these cells may offer new treatments for conditions ranging from diabetes and organ rejection to cancer and infectious diseases. In type II diabetes, moderate inhibition of NF-kB improves glucose tolerance. [Press Release - Hollis-Eden Pharmaceuticals]
Elimination Route
Up to 25% oral bioavailability in mice.
Innovators Monograph
You find simplified version here HE3286
