IL15-Natural Killer Cell Uses, Dosage, Side Effects and more
Natural killer (NK) cells can be incubated with ‘feeder cells’ expressing certain cytokines prior to maturation to enhance their activity. In particular, incubation with IL-15 allows NK cells to lyse a broad range of fresh and cultured tumor targets that the cell is not normally sensitive to.
| Attribute | Details |
|---|---|
| Trade Name | IL15-Natural Killer Cell |
| Generic | IL15-NK Cell |
| IL15-NK Cell Other Names | IL15-Natural Killer Cell |
| Type | |
| Groups | Investigational |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | January 7, 2025 at 1:49 am |
How IL15-Natural Killer Cell works
IL-15 is a key cytokine in NK cell development and function; the IL-15 receptor (IL-15R) is constitutively expressed in both the CD56bright and CD56dim matured NK cells. Activation of the IL-15R involves 3 downstream pathways: JAK1/3/STAT3/5, P13K/Akt/mTOR, and Ras/Raf/MEK/ERK. It was shown that ‘priming’ NK-cells with IL-15 markedly enhanced anti-tumor responses which included cytotoxicity, degranulation, and cytokine production.
