Isosorbide
Isosorbide Uses, Dosage, Side Effects, Food Interaction and all others data.
Isosorbide was previously available in an oral formulation for the reduction of intraocular pressure. It was approved by the FDA in 1980, but has since been discontinued. Currently, isosorbide is an organic nitrate currently available in the isosorbide mononitrate and isosorbide dinitrate forms, and is used for the prevention of angina. Refer to these drug entries for more information.
Isosorbide reduces intraocular pressure through its effects on ocular blood vessels. While in the blood, isosorbide promotes redistribution of water toward the circulation, promoting the excretion of urine.
| Trade Name | Isosorbide |
| Availability | Prescription only |
| Generic | Isosorbide |
| Isosorbide Other Names | Isosorbide |
| Related Drugs | amlodipine, aspirin, lisinopril, metoprolol, furosemide, carvedilol, propranolol, spironolactone, atenolol, diltiazem |
| Type | |
| Formula | C6H10O4 |
| Weight | Average: 146.1412 Monoisotopic: 146.057908808 |
| Groups | Approved, Investigational |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Isosorbide is a vasodilator used for the prevention and treatment of angina pectoris due to coronary artery disease. It was previously used to reduce intraocular pressure.
Isosorbide was previously indicated for temporary reduction of intraocular pressure and used to interrupt an acute glaucoma attack, however, this is not a currently approved indication. Refer to isosorbide mononitrate and isosorbide dinitrate drug entries for more isosorbide indications.
Isosorbide is also used to associated treatment for these conditions: Angina Pectoris
How Isosorbide works
Isosorbide causes vascular relaxation, reducing systolic ophthalmic artery pressure (SOAP), systolic ocular perfusion pressure (SOPP).
Food Interaction
No interactions found.Isosorbide Drug Interaction
Unknown: aspirin, aspirin, rosuvastatin, rosuvastatin, insulin glargine, insulin glargine, furosemide, furosemide, atorvastatin, atorvastatin, metoprolol, metoprolol, nitroglycerin, nitroglycerin, clopidogrel, clopidogrel, acetaminophen, acetaminophen, cholecalciferol, cholecalciferol
Isosorbide Disease Interaction
Major: AMI, anemia, hemodialysis, hypotension, intracranial pressureModerate: hypertrophic cardiomyopathyMinor: glaucoma
Elimination Route
Isosorbide is rapidly absorbed after oral administration. Refer to isosorbide mononitrate for detailed absorption information.
Innovators Monograph
You find simplified version here Isosorbide
