Levallofano
Levallofano Uses, Dosage, Side Effects, Food Interaction and all others data.
An opioid antagonist with properties similar to those of naloxone; in addition it also possesses some agonist properties. It should be used cautiously; levallorphan reverses severe opioid-induced respiratory depression but may exacerbate respiratory depression such as that induced by alcohol or other non-opioid central depressants. (From Martindale, The Extra Pharmacopoeia, 30th ed, p683)
Levallofano, an opioid antagonist similar to naloxone, is used to treat drug overdoses. Levallofano differs from naloxone in that it also possesses some agonist properties. It is an analogue of levelorphanol that counteracts the actions of narcotic analgesics such as morphine. It is used especially in the treatment of respiratory depression due to narcotic overdoses. Levallofano prevents or reverses the effects of opioids including respiratory depression, sedation and hypotension. Also, it can reverse the psychotomimetic and dysphoric effects of agonist-antagonists such as pentazocine.
Trade Name | Levallofano |
Generic | Levallorphan |
Levallorphan Other Names | Levallofano, Levallorphan, Lévallorphane, Levallorphanum, Levalorfano |
Type | |
Formula | C19H25NO |
Weight | Average: 283.4079 Monoisotopic: 283.193614427 |
Groups | Approved |
Therapeutic Class | |
Manufacturer | |
Available Country | |
Last Updated: | September 19, 2023 at 7:00 am |
Uses
For the complete or partial reversal of narcotic depression, including respiratory depression, induced by opioids.
How Levallofano works
Levallofano antagonizes opioid effects by competing for the same receptor sites. It binds to the opioid mu receptor and the nicotinic acetylcholine receptor alpha2/alpha3.
Toxicity
Oral, rat LD50: 109±4 mg/kg
Elimination Route
Rapidly absorbed.
Half Life
1 hour
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