Lotusate
Lotusate Uses, Dosage, Side Effects, Food Interaction and all others data.
Lotusate, also called 5-allyl-5-sec-butylbarbituric acid, is a barbiturate with a short to intermediate duration of action. Lotusate is a schedule III drug in the U.S.
Lotusate is a short to intermediate-acting barbiturate that is a nonselective central nervous system (CNS) depressant. As with other barbiturates, talbutal is capable of producing all levels of CNS mood alteration from excitation to mild sedation, hypnosis, and deep coma. Barbiturates may also induce anesthesia at sufficiently high therapeutic doses.
| Trade Name | Lotusate |
| Generic | Talbutal |
| Talbutal Other Names | sec-Butyl allyl barbituric acid, Talbutal, Talbutale, Talbutalum |
| Type | |
| Formula | C11H16N2O3 |
| Weight | Average: 224.2563 Monoisotopic: 224.116092388 |
| Groups | Approved, Illicit |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
For use as a sedative and hypnotic.
How Lotusate works
Lotusate binds to GABAA receptors at a distinct binding site associated with a Cl- ionopore of the receptor. Upon binding, talbutal increases the duration of time for which the Cl- ionopore is open, leading to prolonged inhibitory effect of GABA at the postsynaptic thalamic neuron.
Toxicity
Acute barbiturate poisoning is associated with symptoms such as drowsiness, confusion, coma, respiratory depression, hypotension, and shock.
Innovators Monograph
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