Lucanthonum

Lucanthonum Uses, Dosage, Side Effects, Food Interaction and all others data.

One of the schistosomicides, it has been replaced largely by hycanthone and more recently praziquantel. (From Martindale The Extrapharmacopoeia, 30th ed., p46). It is currently being tested as a radiation sensitizer.

Although lucanthone has structural and biochemical similarities to Actinomycin D, it has no hematological or gastro-intestinal toxicity at clinically tolerated doses. In trials, Lucanthonum was found to be safe, practical and effective and was proposed for use in clinical protocols for the treatment of cancer. The specificity of lucanthone in combination with radiation for the treatment of brain tumors arises from the fact that lucanthone acts preferentially on cycling cells (most of the normal brain cells are non-cycling) and the fact that lucanthone crosses the blood brain barrier efficiently.

Trade Name Lucanthonum
Generic Lucanthone
Lucanthone Other Names Lucanthone, Lucanthonum, Lucantona
Type
Formula C20H24N2OS
Weight Average: 340.482
Monoisotopic: 340.16093409
Groups Investigational
Therapeutic Class
Manufacturer
Available Country
Last Updated: September 19, 2023 at 7:00 am
Lucanthonum
Lucanthonum

Uses

Intended for use as a radiation sensitizer in the treatment of brain cancer.

How Lucanthonum works

Recent data suggests that lucanthone inhibits post-radiation DNA repair in tumor cells. The ability of lucanthone to inhibit AP endonuclease and topoisomerase II probably account for the specific DNA repair inhibition in irradiated cells.

Elimination Route

Orally available

Innovators Monograph

You find simplified version here Lucanthonum

*** Taking medicines without doctor's advice can cause long-term problems.
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