Mansil Uses, Dosage, Side Effects and more
An anthelmintic with schistosomicidal activity against Schistosoma mansoni, but not against other Schistosoma spp. Mansil causes worms to shift from the mesenteric veins to the liver where the male worms are retained; the female worms return to the mesentery, but can no longer release eggs. (From Martidale, The Extra Pharmacopoeia, 31st ed, p121)
Mansil is an anthelmintic with schistosomicidal activity against Schistosoma mansoni, but not against other Schistosoma spp. Mansil causes worms to shift from the mesenteric veins to the liver where the male worms are retained; the female worms return to the mesentery, but can no longer release egg.
| Trade Name | Mansil |
| Availability | Discontinued |
| Generic | Oxamniquine |
| Type | |
| Formula | C14H21N3O3 |
| Weight | Average: 279.3348 Monoisotopic: 279.158291553 |
| Groups | Approved |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | January 7, 2025 at 1:49 am |
Uses
For treatment of Schistosomiasis caused by Schistosoma mansoni
How Mansil works
Mansil may associate with an irreversible inhibition of the nucleic acid metabolism of the parasites. A hypothesis has been put forth that the drug is activated by a single step, in which a schistosome sulfotransferase enzyme converts oxamniquine into an ester (probably acetate, phosphate, or sulfate). Subsequently, the ester spontaneously dissociates, the resulting electrophilic reactant is capable of alkylation of schistosome DNA.
Drug Interaction
Unknown: aspirin, aspirin, epinephrine, epinephrine, amoxicillin, amoxicillin, RHO Immunoglobulin , RHO Immunoglobulin , mesalamine, mesalamine, azithromycin, azithromycin, ciprofloxacin, ciprofloxacin, dexamethasone, dexamethasone, dextran, low molecular weight, dextran, low molecular weight, heparin, heparin
Disease Interaction
Elimination Route
Well absorbed orally
Half Life
1-2.5 hours
