Metacillin
Metacillin Uses, Dosage, Side Effects, Food Interaction and all others data.
One of the penicillins which is resistant to penicillinase but susceptible to a penicillin-binding protein. It is inactivated by gastric acid so administered by injection.
Metacillin (INN, BAN) or methicillin (USAN) is a narrow spectrum beta-lactam antibiotic of the penicillin class. It is no longer clinically used. Its role in therapy has been largely replaced by flucloxacillin and dicloxacillin, however the term methicillin-resistant Staphylococcus aureus (MRSA) continues to be used to describe Staphylococcus aureus strains resistant to all penicillins.
| Trade Name | Metacillin |
| Generic | Meticillin |
| Meticillin Other Names | Methicillin, Methicillinum, Methycillin, Meticilina, Meticillin, Meticillina, Meticilline, Meticillinum |
| Type | |
| Formula | C17H20N2O6S |
| Weight | Average: 380.415 Monoisotopic: 380.104207072 |
| Groups | Approved, Investigational |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Used to treat infections caused by susceptible Gram-positive bacteria, particularly beta-lactamase-producing organisms such as Staphylococcus aureus that would otherwise be resistant to most penicillins.
How Metacillin works
Similar to other beta-lactam antimicrobials, meticillin blocks synthesis of the bacterial cell wall. Metacillin stops cross-linkage between the peptidoglycan polymer chains, which make up a large portion of gram-positive bacterial cell walls. It does this by binding to and competitively inhibiting the transpeptidase enzyme used by bacteria to cross-link the peptide (D-alanyl-alanine) used in peptidogylcan synthesis.
Elimination Route
Not absorbed following oral administration.
Half Life
25-60 minutes
Innovators Monograph
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