Metacillin

Metacillin Uses, Dosage, Side Effects, Food Interaction and all others data.

One of the penicillins which is resistant to penicillinase but susceptible to a penicillin-binding protein. It is inactivated by gastric acid so administered by injection.

Metacillin (INN, BAN) or methicillin (USAN) is a narrow spectrum beta-lactam antibiotic of the penicillin class. It is no longer clinically used. Its role in therapy has been largely replaced by flucloxacillin and dicloxacillin, however the term methicillin-resistant Staphylococcus aureus (MRSA) continues to be used to describe Staphylococcus aureus strains resistant to all penicillins.

Trade Name Metacillin
Generic Meticillin
Meticillin Other Names Methicillin, Methicillinum, Methycillin, Meticilina, Meticillin, Meticillina, Meticilline, Meticillinum
Type
Formula C17H20N2O6S
Weight Average: 380.415
Monoisotopic: 380.104207072
Groups Approved, Investigational
Therapeutic Class
Manufacturer
Available Country
Last Updated: September 19, 2023 at 7:00 am
Metacillin
Metacillin

Uses

Used to treat infections caused by susceptible Gram-positive bacteria, particularly beta-lactamase-producing organisms such as Staphylococcus aureus that would otherwise be resistant to most penicillins.

How Metacillin works

Similar to other beta-lactam antimicrobials, meticillin blocks synthesis of the bacterial cell wall. Metacillin stops cross-linkage between the peptidoglycan polymer chains, which make up a large portion of gram-positive bacterial cell walls. It does this by binding to and competitively inhibiting the transpeptidase enzyme used by bacteria to cross-link the peptide (D-alanyl-alanine) used in peptidogylcan synthesis.

Elimination Route

Not absorbed following oral administration.

Half Life

25-60 minutes

Innovators Monograph

You find simplified version here Metacillin

*** Taking medicines without doctor's advice can cause long-term problems.
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