Pondocillin

Pondocillin Uses, Dosage, Side Effects, Food Interaction and all others data.

Pivalate ester analog of ampicillin.

Pondocillin is the pivaloyloxymethyl ester of (the semi-synthetic penicillin) ampicillin. It is an inactive pro-drug, which is converted during its absorption from the gastrointestinal tract to the microbiologically active ampicillin, together with formaldehyde and pivalic acid, by non-specific esterases present in most body tissues. Amounts in excess of 99% of the pivampicillin absorbed are converted to ampicillin within 15 minutes of absorption.

Table Of contents

• Pondocillin
• Uses
• Dosage
• Side Effect
• Precautions
• Interactions
• Uses during Pregnancy
• Uses during Breastfeeding
• Accute Overdose
• Food Interaction
• Half Life
• Volume of Distribution
• Clearance
• Interaction With other Medicine
• Contradiction
• Storage

Trade Name	Pondocillin
Generic	Pivampicillin
Pivampicillin Other Names	Ampicillin pivaloyloxymethyl ester, Pivaloylampicillin, Pivaloyloxymethyl ampicillinate, Pivampicilina, Pivampicillin, Pivampicilline, Pivampicillinum
Type
Formula	C22H29N3O6S
Weight	Average: 463.547 Monoisotopic: 463.177706365
Groups	Approved
Therapeutic Class
Manufacturer
Available Country
Last Updated:	September 19, 2023 at 7:00 am

Uses

Pondocillin is an ampicillin prodrug used to treat a variety of infections.

or the treatment of respiratory tract infections (including acute bronchitis, acute exacerbations of chronic bronchitis and pneumonia); ear, nose and throat infections; gynecological infections; urinary tract infections (including acute uncomplicated gonococcal urethritis) when caused by non penicillinase-producing susceptible strains of the following organisms: gram-positive organisms, e.g., streptococci, pneumococci and staphylococci; gram-negative organisms, e.g., H. influenzae, N. gonorrhoeae, E. coli, P. mirabilis.

Pondocillin is also used to associated treatment for these conditions: Susceptible Bacterial Infections

How Pondocillin works

Ampicillin (the active metabolite of pivampicillin) has a bactericidal action resulting from inhibition of cell wall mucopeptide biosynthesis.

Food Interaction

• Take with or without food. The absorption is unaffected by food.

Elimination Route

Absorbed following oral administration.

Half Life

Approximately 1 hour.

Innovators Monograph

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