N-acetyl-tyrosine
N-acetyl-tyrosine Uses, Dosage, Side Effects, Food Interaction and all others data.
N-acetyl-tyrosine, also referred to as N-acetyl-L-tyrosine, is used in place of as a tyrosine precursor. Tyrosine is a non-essential amino acid with a polar side group. N-acetyl-tyrosine is administered as parenteral nutrition or intravenous infusion due to its enhanced solubility compared to tyrosine . It is typically administered as a source of nutritional support where oral nutrition is inadequate or cannot be tolerated.
N-acetyl-tyrosine is used as a high solubility precursor to Tyrosine used due to Tyrosine's poor solubility . It is deacetylated to form Tyrosine.
| Trade Name | N-acetyl-tyrosine |
| Generic | N-acetyltyrosine |
| N-acetyltyrosine Other Names | Acetyl tyrosine, L-N-acetyltyrosine, Melanowhite-A, N-acetyl-tyrosine, N-acetyltyrosin |
| Type | |
| Formula | C11H13NO4 |
| Weight | Average: 223.2252 Monoisotopic: 223.084457909 |
| Groups | Approved |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
N-acetyl-tyrosine is an amino acid used in total parenteral nutrition.
N-acetyl-tyrosine is indicated, in combination with several other amino acids and dextrose, as a peripherally administered source of nitrogen for nutritional support in patients with adequate stores of body fat in whom, for short periods, oral administration cannot be tolerated, is undesirable, or inadequate .
It is also indicated, with other amino acids, 5-10% dextrose, and fat emulsion, for parenteral nutrition to preserve protein and reduce catabolism in stress conditions where oral administration is inadequate .
When administered with other amino acids and concentrated dextrose, it is indicated for central vein infusion to prevent or reverse negative nitrogen balance in patients where the alimentary tract by the oral, gastrostomy, or jejestomy routes cannot or should not be used or in patients in which gastrointestinal absorption of protein is impaired, metabolic requirements for protein are substantially increased, or morbidity and mortality may be reduced by replacing amino acids lost from tissue breakdown
How N-acetyl-tyrosine works
Used as a source of Tyrosine. See Tyrosine for more information on its role and pharmacology.
Food Interaction
No interactions found.Elimination Route
N-acetyl-tyrosine is eliminated in the urine . The extent of urinary elimination versus utilization in the tissues appears to be related to the rapidity of infusion. When infused slowly in standard doses as in the clinical setting, about 35% is excreted unchanged in the urine. When larger doses are infused rapidly, much higher amounts are excreted reaching values up to 56% . In rat studies it was found that of the drug eliminated in the urine about 74% is present as unchanged N-acetyl-tyrosine and 23% is present as tyrosine .
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