OncoScint
OncoScint Uses, Dosage, Side Effects, Food Interaction and all others data.
Tumor associated glycoprotein (TAG) 72 (B72.3) monoclonal antibody conjugated with Indium 111 for radioimaging colon tumors. Satumomab Pendetide (trade name: OncoScint®) is no longer commercially available.
Binds to the tumor associated glycoprotein 72 antigen, which is a cell surface protein generally over-expressed in colorectal cancers. The radioactive Indium 111, which is covalently attached to the antibody, allows radiodiagnostic detection of TAG-72 expressing cells and tumors.
Trade Name | OncoScint |
Generic | Indium In-111 satumomab pendetide |
Indium In-111 satumomab pendetide Other Names | Indium (111In) satumomab pendetide, Indium In 111 satumomab pendetide, Indium-111 satumomab pendetide |
Type | |
Formula | C6268H9708N1666O1971S48 |
Weight | 141478.9 Da |
Groups | Experimental, Withdrawn |
Therapeutic Class | |
Manufacturer | |
Available Country | |
Last Updated: | September 19, 2023 at 7:00 am |
Uses
For diagnosis of extrahepatic malignant cancers
How OncoScint works
Satumomab Pendetide is a monoclonal antibody which is attached to the chelator pentetic acid (DTPA) linked to the tripeptide glycine (G) – L-tyrosine (Y) – L-lysine (K), which chelates Indium 111. Satumomab pendetide binds selectively to cell-surface TAG-72 expressed on colorectal tumors.
Half Life
0.8 hours (mammalian reticulocytes, in vitro)
Innovators Monograph
You find simplified version here OncoScint