Orthoclone OKT3

Orthoclone OKT3 Uses, Dosage, Side Effects, Food Interaction and all others data.

Murine monoclonal antibody specific to CD3 T-cell lymphocyte antigens. More specifically it is a purified murine (mouse) monoclonal antibody, directed against the CD3 (T3) receptor on the surface of human T-cells (T-lymphocytes) cultured using the murine ascites method. Orthoclone OKT3 is 93% monomeric immune globulin G type 2a (IgG2a).

Used in organ transplant prophylaxis, Orthoclone OKT3 or OKT-3 binds specifically to the CD-3 complex, which is involved in antigen recognition and cell stimulation, on the surface of T lymphocytes. Immediately after administration CD-3-positive T lymphocytes are abruptly removed from circulation. It has been effective in reversing corticosteroid-resistant acute rejection in renal, liver, and cardiac transplant recipients.

Orthoclone OKT3
Uses
Dosage
Side Effect
Precautions
Interactions
Uses during Pregnancy
Uses during Breastfeeding
Accute Overdose
Food Interaction
Half Life
Volume of Distribution
Clearance
Interaction With other Medicine
Contradiction
Storage

Trade Name	Orthoclone OKT3
Generic	Muromonab
Muromonab Other Names	Anti-CD3, Muromonab-CD3
Type
Formula	C₆₄₆₀H₉₉₄₆N₁₇₂₀O₂₀₄₃S₅₆
Weight	146189.7 Da
Groups	Approved, Investigational
Therapeutic Class
Manufacturer
Available Country
Last Updated:	September 19, 2023 at 7:00 am

Uses

Orthoclone OKT3 is a monoclonal anti-CD3 antibody used as immunosuppressive therapy in kidney, heart, and liver transplant patients.

For treatment of organ transplant recipients, prevention of organ rejection

Orthoclone OKT3 is also used to associated treatment for these conditions: Kidney Transplant Rejection, Steroid resistant Heart transplant rejection, Steroid resistant hepatic transplant rejection

How Orthoclone OKT3 works

Orthoclone OKT3 binds to the T-cell surface glycoprotein CD3 epsilon chain. It appears to kill CD-3 positive cells by inducing Fc mediated apoptosis, antibody mediated cytotoxicity and complement-dependent cytotoxicity.