Oxibendazole
Oxibendazole Uses, Dosage, Side Effects, Food Interaction and all others data.
Oxibendazole is a polymerase inhibitor in phase III trials for the treatment of helminth intestinal infections.
| Trade Name | Oxibendazole |
| Generic | Oxibendazole |
| Oxibendazole Other Names | Oxibendazole, Oxibendazolo, Oxibendazolum |
| Type | |
| Formula | C12H15N3O3 |
| Weight | Average: 249.2658 Monoisotopic: 249.111341361 |
| Groups | Investigational, Vet approved |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Investigated for use/treatment in infectious and parasitic disease (unspecified) and pediatric indications.
How Oxibendazole works
Oxibendazole causes degenerative alterations in the tegument and intestinal cells of the worm by binding to the colchicine-sensitive site of tubulin, thus inhibiting its polymerization or assembly into microtubules. The loss of the cytoplasmic microtubules leads to impaired uptake of glucose by the larval and adult stages of the susceptible parasites, and depletes their glycogen stores. Degenerative changes in the endoplasmic reticulum, the mitochondria of the germinal layer, and the subsequent release of lysosomes result in decreased production of adenosine triphosphate (ATP), which is the energy required for the survival of the helminth. Due to diminished energy production, the parasite is immobilized and eventually dies.
Innovators Monograph
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