Oxibendazolo

Oxibendazolo Uses, Dosage, Side Effects, Food Interaction and all others data.

Oxibendazolo is a polymerase inhibitor in phase III trials for the treatment of helminth intestinal infections.

Trade Name Oxibendazolo
Generic Oxibendazole
Oxibendazole Other Names Oxibendazole, Oxibendazolo, Oxibendazolum
Type
Formula C12H15N3O3
Weight Average: 249.2658
Monoisotopic: 249.111341361
Groups Investigational, Vet approved
Therapeutic Class
Manufacturer
Available Country
Last Updated: September 19, 2023 at 7:00 am
Oxibendazolo
Oxibendazolo

Uses

Investigated for use/treatment in infectious and parasitic disease (unspecified) and pediatric indications.

How Oxibendazolo works

Oxibendazolo causes degenerative alterations in the tegument and intestinal cells of the worm by binding to the colchicine-sensitive site of tubulin, thus inhibiting its polymerization or assembly into microtubules. The loss of the cytoplasmic microtubules leads to impaired uptake of glucose by the larval and adult stages of the susceptible parasites, and depletes their glycogen stores. Degenerative changes in the endoplasmic reticulum, the mitochondria of the germinal layer, and the subsequent release of lysosomes result in decreased production of adenosine triphosphate (ATP), which is the energy required for the survival of the helminth. Due to diminished energy production, the parasite is immobilized and eventually dies.

Innovators Monograph

You find simplified version here Oxibendazolo

*** Taking medicines without doctor's advice can cause long-term problems.
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