PEG 300
PEG 300 Uses, Dosage, Side Effects, Food Interaction and all others data.
PEG 300 (PEG 300) is a water-miscible polyether with an average molecular weight of 300 g/mol. It is a clear viscous liquid at room temperature with non-volatile, stable properties . Polyethylene glycols are widely used in biochemistry, structural biology, and medicine in addition to pharmaceutical and chemical industries. They serve as solubilizers, excipients, lubricants, and chemical reagents. Low molecular weight glycols are observed to exhibit antibacterial properties as well. PEG 300 is found in eye drops as a lubricant to temporarily relieve redness, burning and irritation of the eyes.
PEGs act as nonionic surfactant to decrease surface tension and condition the stratum corneum, thus enhance the diffusion of other molecules or drugs through the skin .
Trade Name | PEG 300 |
Generic | Polyethylene glycol 300 |
Polyethylene glycol 300 Other Names | Macrogol 300, PEG 300, PEG-6 |
Type | |
Protein binding | No pharmacokinetic data available. |
Groups | Approved |
Therapeutic Class | |
Manufacturer | |
Available Country | |
Last Updated: | September 19, 2023 at 7:00 am |
Uses
Indicated as a lubricant in over-the-counter ophthalmic solutions to temporarily relieve redness, burning and irritation of the eyes.
How PEG 300 works
Due to their physical properties, PEG acts as a surfactant by coating the eye. It provides lubrication and surface protection in dry eyes.
Toxicity
Oral LD50 in rat and mouse are 27500 mg/kg and 31000 mg/kg, respectively . Dermal LD50 is reported to be 20000 mg/kg in rabbit . PEGs and their derivatives are not known to cause ocular and dermal irritation, and are associated with low acute and chronic toxicities .
Food Interaction
No interactions found.Volume of Distribution
No pharmacokinetic data available.
Elimination Route
PEGs can be absorbed by the gastrointestinal tract following oral administration with the fraction absorbed being dependent on the molecular weight of the compound . It is likely to display minimal absorption through the intact skin, but may penetrate through injured skin with compromised barrier function .
Half Life
No pharmacokinetic data available.
Clearance
No pharmacokinetic data available.
Elimination Route
After oral and intravenous exposure, PEGs are excreted mainly unchanged in the urine and faeces .
Innovators Monograph
You find simplified version here PEG 300