Pegpleranib

Pegpleranib Uses, Dosage, Side Effects, Food Interaction and all others data.

Trade Name Pegpleranib
Generic Pegpleranib
Pegpleranib Other Names Pegpleranib
Type
Groups Investigational
Therapeutic Class
Manufacturer
Available Country
Last Updated: September 19, 2023 at 7:00 am
Pegpleranib
Pegpleranib

Uses

Investigated for use/treatment in macular degeneration and eye disorders/infections.

How Pegpleranib works

E10030 is an aptamer based, anti-platelet-derived growth factor (PDGF) which inhibits PDGF-B with high specificity and affinity. E10030 may be efficacious in treating neovascular age-related macular degeneration when combined with a vascular endothelial growth factor A (VEGF-A) inhibitor. PDGF-B is implicated in vascular stability and function through its role in activating the recruitment of mural cells (pericytes) by endothelial cells to envelop the developing vasculature. Pericyte recruitment is part of the maturation process in blood vessel development and pericytes act as support cells for mature blood vessels. [Opthotech Corp. Website] Neovascular age-related macular degeneration is a condition where new, extremely fragile blood vessels under the retina where they burst and cause damage to surrounding tissue, resulting in vision problems.

Innovators Monograph

You find simplified version here Pegpleranib


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