Penglobe

Penglobe Uses, Dosage, Side Effects, Food Interaction and all others data.

Penglobe is a prodrug of ampicillin and is microbiologically inactive. It is absorbed following oral administration. During absorption from the gastrointestinal tract, bacampicillin is hydrolyzed by esterases present in the intestinal wall. It is microbiologically active as ampicillin, and exerts a bactericidal action through the inhibition of the biosynthesis of cell wall mucopeptides. It is used to cure infection of upper and lower respiratory tract; skin and soft tissue; urinary tract and acute uncomplicated gonococcal urethritis etc.

Penglobe is a prodrug of ampicillin and is microbiologically inactive.

Penglobe
Uses
Dosage
Side Effect
Precautions
Interactions
Uses during Pregnancy
Uses during Breastfeeding
Accute Overdose
Food Interaction
Half Life
Volume of Distribution
Clearance
Interaction With other Medicine
Contradiction
Storage

Trade Name	Penglobe
Availability	Discontinued
Generic	Bacampicillin
Bacampicillin Other Names	Bacampicilina, Bacampicillin, Bacampicilline, Bacampicillinum
Related Drugs	amoxicillin, doxycycline, ciprofloxacin, cephalexin, metronidazole, azithromycin, clindamycin, ceftriaxone, levofloxacin, Augmentin
Weight	400mg, 200mg,
Type	Tablet
Formula	C₂₁H₂₇N₃O₇S
Weight	Average: 465.52 Monoisotopic: 465.156970923
Groups	Approved, Investigational
Therapeutic Class
Manufacturer	Astrazeneca Pharma India Ltd
Available Country	India,
Last Updated:	September 19, 2023 at 7:00 am

Uses

Penglobe is an ampicillin prodrug used to treat various susceptible bacterial infections in the body, such as respiratory infections and skin and subcutaneous tissue infections.

For infections at the following sites: upper and lower respiratory tract; skin and soft tissue; urinary tract and acute uncomplicated gonococcal urethritis, when due to sensitive strains of the following organisms: Gram-positive: streptococci (including S. faecalis and S. pneumoniae) and nonpenicillinase-producing staphylococci; Gram-negative: H. influenzae, N. gonorrhoeae, E. coli, P. mirabilis, Salmonellae and Shigellae.

Penglobe is also used to associated treatment for these conditions: Genital infection, Infections, Intestinal, Lower Respiratory Tract Infection (LRTI), Oral Infection, Pneumonia, Skin and Subcutaneous Tissue Bacterial Infections, Upper Respiratory Tract Infection, Urinary Tract Infection, Susceptible Bacterial Infections

How Penglobe works

During absorption from the gastrointestinal tract, bacampicillin is hydrolyzed by esterases present in the intestinal wall. It is microbiologically active as ampicillin, and exerts a bactericidal action through the inhibition of the biosynthesis of cell wall mucopeptides.

Food Interaction

Take separate from antacids. Elevated gastric pH may reduce the bioavailability of bacampicillin.
Take with or without food. Food may reduce the bioavailability of bacampicillin.