Pivanex

Pivanex Uses, Dosage, Side Effects, Food Interaction and all others data.

Pivaloyloxymethyl butyrate (Pivanex), an acyloxyalkyl ester prodrug of butyric acid (BA), exhibited low toxicity and significant anticancer activity in vitro and in vivo. It shows greater potency than BA at inducing malignant cell differentiation and tumor growth inhibition and has demonstrated more favorable toxicological, pharmacological, and pharmaceutical properties than BA in preclinical studies.

Table Of contents

• Pivanex
• Uses
• Dosage
• Side Effect
• Precautions
• Interactions
• Uses during Pregnancy
• Uses during Breastfeeding
• Accute Overdose
• Food Interaction
• Half Life
• Volume of Distribution
• Clearance
• Interaction With other Medicine
• Contradiction
• Storage

Trade Name	Pivanex
Generic	AN-9
AN-9 Other Names	Pivaloyloxymethyl butyrate, Pivaloyloxymethylbutyrate, Pivanex
Type
Formula	C10H18O4
Weight	Average: 202.25 Monoisotopic: 202.12050906
Groups	Investigational
Therapeutic Class
Manufacturer
Available Country
Last Updated:	September 19, 2023 at 7:00 am

Uses

Investigated for use/treatment in liver cancer, lung cancer, melanoma, and leukemia (lymphoid).

How Pivanex works

Pivaloyloxymethyl butyrate is a histone deacetylase inhibitor analog of butyric acid that causes apoptosis of cancer cells through signaling cellular differentiation. It is rapidly and extensively transported intracellularly because of its high lipophilicity, where it undergoes esterase-mediated hydrolysis to form pivalic acid, formaldehyde, and BA.

Innovators Monograph

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