Porcine Insulin Uses, Dosage, Side Effects and more
Insulin isolated from pig pancreas. Composed of alpha and beta chains, processed from pro-insulin. Forms a hexameric structure.
Insulin is used in the treatment of type I and type II diabetes. The primary activity of insulin is the regulation of glucose metabolism. In muscle and other tissues (except the brain), insulin causes rapid transport of glucose and amino acids intracellularly. It also promotes anabolism, and inhibits protein catabolism. In the liver, insulin promotes the uptake and storage of glucose in the form of glycogen, inhibits gluconeogenesis, and promotes the conversion of excess glucose into fat.
| Trade Name | Porcine Insulin |
| Generic | Insulin pork |
| Insulin pork Other Names | Insulin (pork), Insulin porcine, Insulin purified porcine, Insulin purified pork, Insulin, porcine, Insulin, regular, pork, Porcine insulin |
| Type | |
| Formula | C257H387N65O76S6 |
| Weight | 5795.6 Da |
| Groups | Approved |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | January 7, 2025 at 1:49 am |
Uses
Porcine Insulin is a purified form of porcine insulin used to control hyperglycemia in diabetes mellitus.
For the treatment of type I and II diabetes mellitus.
Porcine Insulin is also used to associated treatment for these conditions: Insulin Dependent Diabetes, Type 1 Diabetes Mellitus
How Porcine Insulin works
Insulin binds to the insulin receptor (IR), a heterotetrameric protein consisting of two extracellular alpha units and two transmembrane beta units. The binding of insulin to the alpha subunit of IR stimulates the tyrosine kinase activity intrinsic to the beta subunit of the receptor. The bound receptor is able to autophosphorylate and phosphorylate numerous intracellular substrates such as insulin receptor substrates (IRS) proteins, Cbl, APS, Shc and Gab 1. These activated proteins, in turn, lead to the activation of downstream signaling molecules including PI3 kinase and Akt. Akt regulates the activity of glucose transporter 4 (GLUT4) and protein kinase C (PKC) which play a critical role in metabolism.
Food Interaction
- Avoid excessive or chronic alcohol consumption. Drinking more than two standard drinks per day in women, or more than 3 standard drinks per day in men, can reduce a patient's insulin requirements, and therefore increase the risk of hypoglycemia if the insulin dosing is not adjusted.
